Defining immunological impact and therapeutic benefit of mild heating in a murine model of arthritis

PloS One
Chen-Ting LeeElizabeth A Repasky

Abstract

Traditional treatments, including a variety of thermal therapies have been known since ancient times to provide relief from rheumatoid arthritis (RA) symptoms. However, a general absence of information on how heating affects molecular or immunological targets relevant to RA has limited heat treatment (HT) to the category of treatments known as "alternative therapies". In this study, we evaluated the effectiveness of mild HT in a collagen-induced arthritis (CIA) model which has been used in many previous studies to evaluate newer pharmacological approaches for the treatment of RA, and tested whether inflammatory immune activity was altered. We also compared the effect of HT to methotrexate, a well characterized pharmacological treatment for RA. CIA mice were treated with either a single HT for several hours or daily 30 minute HT. Disease progression and macrophage infiltration were evaluated. We found that both HT regimens significantly reduced arthritis disease severity and macrophage infiltration into inflamed joints. Surprisingly, HT was as efficient as methotrexate in controlling disease progression. At the molecular level, HT suppressed TNF-α while increasing production of IL-10. We also observed an induction of HSP70 and a...Continue Reading

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Citations

Feb 7, 2016·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Mark W DewhirstKathleen A Ashcraft
May 16, 2015·Nature Reviews. Immunology·Sharon S EvansDaniel T Fisher
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Nov 7, 2016·Pathogens and Disease·Alexandria M Palaferri Schieber, Janelle S Ayres
Dec 5, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Bonnie L Hylander, Elizabeth A Repasky

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Methods Mentioned

BETA
flow cytometry
FCS
ELISA
lavage
nuclear translocation
immunoprecipitation
PCR
protein assay
flow

Software Mentioned

ImageStream
FCS Express

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