Defining incidence and risk factors of venous thromboemolism after hepatectomy

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Aslam EjazTimothy M Pawlik

Abstract

The incidence of venous thromboembolism (VTE) among patients undergoing hepatic surgery is poorly defined, leading to varied use of VTE prophylaxis among surgeons. We sought to define the incidence of VTE after liver surgery and identify risk factors associated with VTE. Incidence of VTE and associated risk factors within 90 days of hepatic resection between 2006 and 2012 at a major academic center was analyzed. Risk factors for VTE were identified using univariate and multivariate analyses. A total of 599 patients were included in the study cohort; 30 (5.0 %) had a prior history of VTE. The indications for surgery were malignant (90.8 %) and benign lesions (9.2 %). The majority of patients underwent a minor hepatectomy (<3 Couinaud segments; n = 402, 67.1 %) while 195 (32.6 %) patients underwent a major hepatectomy (≥3 Couinaud segments). Three hundred seven (51.3 %) patients were started on VTE chemoprophylaxis preoperatively with 407 (67.8 %) patients receiving VTE chemoprophylaxis within 24 h of surgery. Twenty-eight (4.7 %) patients developed VTE; 20 (3.3 %) had deep venous thrombosis (DVT), 11 (1.8 %) had pulmonary embolism (PE), and three (0.5 %) developed both DVT and PE. Among the VTE patients, 23 (82.1 %) had received...Continue Reading

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Citations

Apr 1, 2016·Anaesthesia·S V MallettP Chowdary
Oct 1, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Madeline LemkePaul J Karanicolas
Dec 8, 2016·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Michael B StreiffElliott R Haut
Jan 31, 2018·Anesthesia and Analgesia·Jennifer T MallekLinda Le-Wendling
Oct 23, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Thomas A AloiaGiles J Toogood
Apr 1, 2016·Anaesthesia·M A E Ramsay, J F Trotter
Mar 24, 2016·The British Journal of Surgery·D J GroeneveldT Lisman
Oct 31, 2020·Journal of Thrombosis and Haemostasis : JTH·Sarah BosTon Lisman
Sep 30, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Cary Jo R SchlickDavid J Bentrem
Nov 13, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Michail N MavrosJulie Hallet
Nov 24, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Eppu AinoaVille Sallinen

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