Defining Low Prognosis Patients Undergoing Assisted Reproductive Technology: POSEIDON Criteria-The Why

Frontiers in Endocrinology
Sandro C EstevesCarlo Alviggi

Abstract

Women with impaired ovarian reserve or poor ovarian response (POR) to exogenous gonadotropin stimulation present a challenge for reproductive specialists. The primary reasons relate to the still limited knowledge about the POR pathophysiology and the lack of practical solutions for the management of these conditions. Indeed, clinical trials using the current standards to define POR failed to show evidence in favor of a particular treatment modality. Furthermore, critical factors for reproductive success, such as the age-dependent embryo aneuploidy rates and the intrinsic ovarian resistance to gonadotropin stimulation, are not taken into consideration by the current POR criteria. As a result, the accepted definitions for POR have been criticized for their inadequacy concerning the proper patient characterization and for not providing clinicians a guide for therapeutic management. A novel system to classify infertility patients with "expected" or "unexpected" inappropriate ovarian response to exogenous gonadotropins-the POSEIDON criteria-was developed to provide a more nuanced picture of POR and to guide physicians in the management of such patients. The new standards are provoking as they challenge the current terminology of POR...Continue Reading

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Citations

Nov 23, 2019·Human Reproduction·Jori A LeijdekkersFrank J M Broekmans
Apr 20, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Rui HuangXiao-Yan Liang
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Sep 12, 2019·Frontiers in Endocrinology·Ali AbbaraWaljit S Dhillo
Dec 12, 2019·Frontiers in Endocrinology·Sandro C EstevesFilippo M Ubaldi
Sep 17, 2020·Diagnostics·Polina GiannelouKonstantinos Sfakianoudis
Feb 8, 2019·Reproductive Biology and Endocrinology : RB&E·Alessandro ConfortiCarlo Alviggi
May 30, 2019·Frontiers in Endocrinology·Valentina GrisendiAntonio La Marca
Feb 11, 2020·Frontiers in Endocrinology·Klaus F Bühler
Jul 19, 2019·Frontiers in Endocrinology·Alessandro ConfortiCarlo Alviggi
May 2, 2019·Frontiers in Endocrinology·Michael Grynberg, Julie Labrosse
Jul 12, 2019·Frontiers in Endocrinology·Alessandro ConfortiCarlo Alviggi
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Apr 6, 2021·Frontiers in Endocrinology·Sandro C EstevesCarlo Alviggi
May 4, 2021·Frontiers in Endocrinology·Jingyi WenShixuan Wang
Jul 16, 2021·Therapeutic Advances in Reproductive Health·Cristina Rodríguez-VarelaElena Labarta

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