Defining Myocardial Abnormalities Across the Stages of Chronic Kidney Disease: A Cardiac Magnetic Resonance Imaging Study.

JACC. Cardiovascular Imaging
Manvir K HayerBirmingham Cardio-Renal Group

Abstract

A proof of concept cross-sectional study investigating changes in myocardial abnormalities across stages of chronic kidney disease (CKD). Characterizing noninvasive markers of myocardial fibrosis on cardiac magnetic resonance, echocardiography, and correlating with biomarkers of fibrosis, myocardial injury, and functional correlates including exercise tolerance. CKD is associated with an increased risk of cardiovascular death. Much of the excess mortality is attributed to uremic cardiomyopathy, defined by increased left ventricular hypertrophy, myocardial dysfunction, and fibrosis. The prevalence of these abnormalities across stages of CKD and their impact on cardiovascular performance is unknown. A total of 134 nondiabetic, pre-dialysis subjects with CKD stages 2 to 5 without myocardial ischemia underwent cardiac magnetic resonance (1.5-T) including; T1 mapping (biomarker of diffuse fibrosis), T2 mapping (edema), late gadolinium enhancement, and assessment of aortic distensibility. Serum biomarkers including collagen turnover (P1NP, P3NP), troponin T, and N-terminal pro-B-type natriuretic peptide were measured. Cardiovascular performance was quantified by bicycle cardiopulmonary exercise testing and echocardiography. Native my...Continue Reading

Associated Clinical Trials

References

Jun 30, 2010·Circulation·Gary J BaladyUNKNOWN Interdisciplinary Council on Quality of Care and Outcomes Research
Oct 14, 2011·Kidney International·William G CouserMarcello Tonelli
Nov 16, 2013·Journal of the American Society of Nephrology : JASN·Stephen M S TingDaniel Zehnder
Mar 15, 2015·The American Journal of Cardiology·Nicola C EdwardsRichard P Steeds
Jun 6, 2015·Journal of the American College of Cardiology·Begoña LópezJavier Díez
May 27, 2016·Lancet·Christoph WannerTetsuo Shoji
Sep 24, 2016·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Gabriella CapturJames C Moon
May 18, 2017·Scientific Reports·Alexander GrabnerChristian Faul
Jun 6, 2017·The American Journal of Cardiology·Liselotte C R HensenJeroen J Bax
Jun 6, 2018·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Courtney TuegelNisha Bansal
Jul 6, 2019·International Journal of Cardiology·Manvir K HayerRichard P Steeds

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