Defining myocardial fibrosis in haemodialysis patients with non-contrast cardiac magnetic resonance.

BMC Cardiovascular Disorders
M P M Graham-BrownG P McCann

Abstract

Extent of myocardial fibrosis (MF) determined using late gadolinium enhanced (LGE) predicts outcomes, but gadolinium is contraindicated in advanced renal disease. We assessed the ability of native T1-mapping to identify and quantify MF in aortic stenosis patients (AS) as a model for use in haemodialysis patients. We compared the ability to identify areas of replacement-MF using native T1-mapping to LGE in 25 AS patients at 3 T. We assessed agreement between extent of MF defined by LGE full-width-half-maximum (FWHM) and the LGE 3-standard-deviations (3SD) in AS patients and nine T1 thresholding-techniques, with thresholds set 2-to-9 standard-deviations above normal-range (1083 ± 33 ms). A further technique was tested that set an individual T1-threshold for each patient (T11SD). The technique that agreed most strongly with FWHM or 3SD in AS patients was used to compare extent of MF between AS (n = 25) and haemodialysis patients (n = 25). Twenty-six areas of enhancement were identified on LGE images, with 25 corresponding areas of discretely increased native T1 signal identified on T1 maps. Global T1 was higher in haemodialysis than AS patients (1279 ms ± 5.8 vs 1143 ms ± 12.49, P < 0.01). No signal-threshold technique derived fro...Continue Reading

Associated Clinical Trials

References

Jan 1, 1990·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G MallE Ritz
May 27, 2003·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Daniel R MessroghliMatthias G Friedrich
Jun 15, 2004·Journal of the American College of Cardiology·James C C MoonDudley J Pennell
Jul 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Daniel R MessroghliJohn P Ridgway
Dec 21, 2004·Journal of the American College of Cardiology·Luciano C AmadoJoão A C Lima
Apr 25, 2006·European Radiology·Pierre CroisilleMaythem Saeed
Nov 23, 2006·Journal of the American College of Cardiology·Ravi G AssomullDudley J Pennell
Apr 13, 2007·The International Journal of Cardiovascular Imaging·Elizabeth KehrMichael Jerosch-Herold
Jul 31, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Daniel R MessroghliMohan U Sivananthan
Mar 11, 2009·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Aernout M BeekAlbert C van Rossum
May 2, 2009·Journal of the American College of Cardiology·Andreas KribbenRaimund Erbel
Feb 19, 2011·Journal of the American College of Cardiology·Nathan MewtonJoão A C Lima
Sep 2, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Andrew E Arai
Sep 10, 2011·Journal of the American College of Cardiology·Marc R DweckSanjay K Prasad
Sep 21, 2011·Future Cardiology·Daniel M SadoJames C Moon
May 29, 2012·European Heart Journal Cardiovascular Imaging·Andrew S FlettJames C Moon
Oct 16, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·James C MoonUNKNOWN Cardiovascular Magnetic Resonance Working Group of the European Society of Cardiology
Oct 16, 2014·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Yoko MikamiJames A White
Oct 23, 2015·European Heart Journal·Calvin W L ChinMarc R Dweck
Mar 24, 2016·Clinical Radiology·R J EverettS Mirsadraee
Jan 18, 2017·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Pan Ki KimByoung Wook Choi
Jan 27, 2017·Journal of the American Society of Nephrology : JASN·Charlotte BuchananChris W McIntyre
Feb 28, 2017·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Matthew P M Graham-BrownGerry P McCann

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Citations

Feb 20, 2021·Journal of Magnetic Resonance Imaging : JMRI·Hang ZhouShan Mou
May 8, 2021·European Journal of Radiology·Matthew P M Graham-BrownGerry P McCann
May 14, 2021·Circulation·Gautam R ShroffUNKNOWN American Heart Association Council on the Kidney in Cardiovascular Disease and Stroke Council
May 24, 2021·Kidney International·Matthew P M Graham-BrownJames O Burton

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Clinical Trials Mentioned

ISRCTN11299707
NCT01658345

Software Mentioned

CMR42
CMR
Graphpad Prism
SPSS
Argus Viewer
GraphPad

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