Defining optimal duration and predicting benefit from chemotherapy in patients with luminal-like subtypes

The Breast : Official Journal of the European Society of Mastology
Christopher D HartAngelo Di Leo

Abstract

The molecular subtypes of breast cancer have individual patterns of behaviour, prognosis and sensitivity to treatment, with subsequent implications for the choice of, or indeed role for adjuvant therapy. The luminal A and B subtypes make up the majority of breast cancers, but despite sharing expression of the oestrogen receptor (ER), they are molecularly distinct. It follows then that they would have different sensitivities to chemotherapy. Clinically, luminal A disease has a better prognosis than luminal B, and may not derive significant benefit from adjuvant chemotherapy. However no prospective trials have specifically investigated the benefit of adjuvant chemotherapy in each subtype, nor do we know if certain agents are more or less effective. This paper will briefly summarise the role of molecular profiles in assessing the need for chemotherapy and predicting its effectiveness, followed by an assessment of the relative value of newer anthracycline- or taxane-containing regimes in the luminal-like subtypes, providing a review of retrospective analyses.

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Citations

May 6, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A S CoatesUNKNOWN Panel Members
Apr 28, 2016·The Breast : Official Journal of the European Society of Mastology·Serena Di CosimoValter Torri
Jul 12, 2019·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Qiao XuYongjie Ma
Jun 22, 2019·Breast Cancer Research and Treatment·Edoardo IsnaldiGabriele Zoppoli
Jun 20, 2019·Frontiers in Oncology·Nawale HajjajiJacques Bonneterre
Jun 9, 2020·Oncology Research and Treatment·Elisa ZanardiAlessandra Rubagotti

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