PMID: 22333410Feb 16, 2012Paper

Defining patients at extremely high risk for coronary artery disease in heterozygous familial hypercholesterolemia

Journal of Atherosclerosis and Thrombosis
Takako SugisawaMariko Harada-Shiba

Abstract

Heterozygous patients with familial hypercholesterolemia (FH) are known to be associated with a high risk of coronary artery disease (CAD), which is a major determinant of their clinical outcome. The prognosis of heterozygous FH patients substantially varies, being dependent on the level of their CAD risk, and their therapeutic regimen should be individualized. We assessed critical levels of LDL-cholesterol (LDL-C) and Achilles tendon thickness (ATT) to identify heterozygous FH patients at "very high" risk for CAD. One hundred and nine heterozygous FH patients who had no history of CAD and had had their plasma lipid profile and ATT assessed before treatment were followed up until their first CAD event or 31 December 2010. Multivariable logistic regression models were used to analyze the correlation of LDL-C and/or ATT levels with the risk of developing CAD. During the follow-up period, 21 of the 109 patients had a CAD event, diagnosed by coronary angiogram. Individuals in the highest tertile of LDL-C had a CAD risk 8.29-fold higher than those in the lowest tertile. Individuals in the highest tertile of the ATT group had a 7.82-fold higher CAD risk than those in the lowest tertile. Those who had either LDL-C ≥ 260 mg/dL or ATT ≥...Continue Reading

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Citations

Jan 1, 2014·Molekuliarnaia biologiia·J JiangL Wang
Mar 8, 2016·Journal of Atherosclerosis and Thrombosis·Sang-Hak Lee
Jan 27, 2017·International Heart Journal·Hirotoshi OhmuraUNKNOWN Research Committee on Primary Hyperlipidemia of the Ministry of Health and Welfare of Japan
Jun 28, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Masahito MichikuraMariko Harada-Shiba
Jun 8, 2018·Journal of Atherosclerosis and Thrombosis·Mariko Harada-ShibaUNKNOWN Working Group by Japan Atherosclerosis Society for Making Guidance of Familial Hypercholesterolemia
Nov 7, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Masatsune OguraMariko Harada-Shiba
Oct 26, 2012·Journal of Atherosclerosis and Thrombosis·Mariko Harada-ShibaShizuya Yamashita
Mar 2, 2017·Medical Molecular Morphology·Masa-Aki ShibataMariko Harada-Shiba

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