Defining radiotherapy target volumes using 18F-fluoro-deoxy-glucose positron emission tomography/computed tomography: still a Pandora's box?

International Journal of Radiation Oncology, Biology, Physics
Slobodan DevicShirley Lehnert

Abstract

We discuss the effect of (18)F-fluoro-deoxy-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) data on target volume definition for radiotherapy planning. We compared the effect of various thresholding methods on the PET-based target volume vs. the standard CT-based tumor volume. Different thresholding methods were reviewed and compared to our PET-based gross tumor volume data obtained from a cohort of 31 non-small-cell lung carcinoma patients who had undergone preoperative PET/CT scans for staging. The feasibility and limitations of FDG-based PET/CT data on target volume delineation in radiotherapy planning have been demonstrated with frequently used approaches for target outlining such as the qualitative visual method and the fixed 15% or 40% of the maximal iso-uptake value threshold methods. The relationship between PET-based and CT-based volumes generally suffers from poor correlation between the two image data sets, expressed in terms of a large statistical variation in gross tumor volume ratios, irrespective of the threshold method used. However, we found that the maximal signal/background ratios in non-small-cell lung carcinoma patients correlated well with the pathologic results, with an average r...Continue Reading

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Citations

Jan 5, 2013·Journal of Radiation Research·Chikae KajitaniMasatoshi Hasegawa
Jun 6, 2012·International Journal of Molecular Imaging·Katsuyuki ShiraiTakashi Nakano
Dec 11, 2014·Journal of Applied Clinical Medical Physics·Hannah M Thomas TE James J Samuel
Mar 27, 2015·Radiology and Oncology·Stasa Jelercic, Mirjana Rajer
Aug 7, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sébastien ThureauPierre Vera

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