Defining robustness protocols: a method to include and evaluate robustness in clinical plans

Physics in Medicine and Biology
S E McGowanA J Lomax

Abstract

We aim to define a site-specific robustness protocol to be used during the clinical plan evaluation process. Plan robustness of 16 skull base IMPT plans to systematic range and random set-up errors have been retrospectively and systematically analysed. This was determined by calculating the error-bar dose distribution (ebDD) for all the plans and by defining some metrics used to define protocols aiding the plan assessment. Additionally, an example of how to clinically use the defined robustness database is given whereby a plan with sub-optimal brainstem robustness was identified. The advantage of using different beam arrangements to improve the plan robustness was analysed. Using the ebDD it was found range errors had a smaller effect on dose distribution than the corresponding set-up error in a single fraction, and that organs at risk were most robust to the range errors, whereas the target was more robust to set-up errors. A database was created to aid planners in terms of plan robustness aims in these volumes. This resulted in the definition of site-specific robustness protocols. The use of robustness constraints allowed for the identification of a specific patient that may have benefited from a treatment of greater individu...Continue Reading

References

Jan 1, 1992·Radiation and Environmental Biophysics·S Scheib, E Pedroni
Sep 1, 1983·Medical Physics·M Goitein
Mar 11, 1999·Physics in Medicine and Biology·A Lomax
Apr 25, 2001·Medical Physics·A J LomaxL Wisser
Dec 4, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·L CozziA Bolsi
Sep 27, 2003·The British Journal of Radiology·S Webb
May 3, 2007·Physics in Medicine and Biology·Jan UnkelbachThomas Bortfeld
May 9, 2008·Clinical Oncology : a Journal of the Royal College of Radiologists·B Jones
Jul 22, 2008·International Journal of Radiation Oncology, Biology, Physics·Alessandra BolsiEugen Hug
Apr 24, 2009·International Journal of Radiation Oncology, Biology, Physics·Carmen AresGudrun Goitein
Apr 28, 2011·Medical Physics·Albin FredrikssonBjörn Hårdemark
Jun 29, 2011·Physics in Medicine and Biology·F AlbertiniA J Lomax
Jul 20, 2011·Acta Oncologica·Yasmin Lassen-RamshadJørgen B B Petersen
Jan 10, 2012·Physics in Medicine and Biology·Wei ChenDavid Craft
Feb 11, 2012·Medical Physics·Wei LiuRadhe Mohan
Feb 14, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Dirk De RuysscherMadelon Pijls-Johannesma
Mar 13, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Aaron M AllenAndre A Konski
Dec 21, 2012·The British Journal of Radiology·S E McGowanA J Lomax
Feb 9, 2013·Physics in Medicine and Biology·M CasiraghiA J Lomax

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Citations

Sep 5, 2015·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·L FeuvretR Ferrand
Apr 17, 2016·International Journal of Radiation Oncology, Biology, Physics·Robert MalyapaFrancesca Albertini
May 13, 2015·Clinical Oncology : a Journal of the Royal College of Radiologists·C S BoonP Sanghera
Mar 11, 2018·Journal of Applied Clinical Medical Physics·Xin ZhangJose Penagaricano
Sep 19, 2017·Journal of Applied Clinical Medical Physics·Kristin StützerChristian Richter
Nov 12, 2019·Radiation Protection Dosimetry·Matěj NavrátilAlexander Grebenyuk
Jan 23, 2020·Acta Oncologica·Katrin HåkanssonIvan R Vogelius
Aug 3, 2020·Medical Physics·Niklas WahlMark Bangert
May 27, 2016·Physics in Medicine and Biology·Zoltán PerkóDanny Lathouwers
May 9, 2019·The British Journal of Radiology·Damien C WeberAlessia Pica

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