Defining T-cell-mediated immune responses in rotavirus-infected juvenile rhesus macaques

Journal of Virology
Karol SestakRichard L Ward

Abstract

The appearance of virus-specific CD4(+) and/or CD8(+) T lymphocytes in peripheral blood of captive juvenile rhesus macaques (Macaca mulatta) was observed following rotavirus infection. These cell-mediated immune responses were measured following experimental or natural infection after rotavirus was isolated from stool specimens of asymptomatic animals. The virus isolated was a new strain of simian rotavirus that we named TUCH (for Tulane University and Cincinnati Children's Hospital). Restimulation of peripheral T lymphocytes by inactivated double- or triple-layered TUCH rotavirus particles containing either VP6 or VP4 and VP7 on their respective surfaces resulted in increased quantities of interleukin-6 (IL-6) and IL-12 in cell culture supernatants. Recall responses to rotavirus by CD4(+) and CD8(+) T lymphocytes were associated with accumulation of intracellular IL-6 and gamma interferon. Antigen presentation of TUCH rotavirus to lymphocytes was mediated via differentiated cultures of monocyte-derived dendritic (HLA-DR(+)) cells. This is the first report demonstrating cell-mediated immune responses to rotavirus in nonhuman primates. Further exploration of rhesus macaques in vaccine trials with human rotavirus vaccine candidat...Continue Reading

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Citations

Dec 17, 2009·Journal of Virology·Delia V Lopez-GuerreroFernando R Esquivel-Guadarrama
Nov 12, 2005·Journal of Virology·Carlos F NarváezManuel A Franco
Aug 19, 2007·Comparative Immunology, Microbiology and Infectious Diseases·Nathalie Parez
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Apr 13, 2010·The Journal of Allergy and Clinical Immunology·Christopher L Karp
Oct 12, 2018·Viruses·Karol Sestak
Aug 23, 2020·Viruses·Heyde MakimaaMegan T Baldridge

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