PMID: 11923113Mar 30, 2002Paper

Defining the dynamics of self-assembled Fas-receptor activation

Trends in Immunology
Suneel D Mundle, Azra Raza

Abstract

Fas-Fas-ligand, the most well investigated apoptotic signaling system, plays a pivotal role in several human diseases. Its signaling through multiple pathways; multiple, complex regulatory points; and recently described tendency to undergo ligand-independent self-assembly warrant a comprehensive understanding of its physiologically well controlled function. In this review, we attempt to develop such a perspective on the regulation of Fas signaling. The multistep Fas regulation model presented here should be helpful in devising effective interventions for conditions resulting from the dysregulation of Fas.

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Citations

Jul 13, 2005·The Journal of Experimental Medicine·Michihiko MiyajiHisanori Umehara
Jul 25, 2009·Blood·Kay KlapprothThomas Wirth
Dec 2, 2005·Journal of Perinatal Medicine·Donna M Neale, Gil Mor
Oct 16, 2004·International Journal of Hematology·Gurveen SaberwalSuneel D Mundle
Apr 16, 2003·Journal of Neurochemistry·Karolina WosikJosephine Nalbantoglu
Aug 29, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Norma Serrano-GarcíaCristina Trejo-Solís
Apr 25, 2003·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·D NealeG Mor
Apr 18, 2014·Journal of Integrative Neuroscience·Eva Čadež
Aug 7, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Delia MezzanzanicaSilvana Canevari

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