Defining the osteoarthritis patient: back to the future

Osteoarthritis and Cartilage
G P DobsonJ L Morris

Abstract

The history of osteoarthritis (OA) is important because it can help broaden our perspective on past and present controversies. The naming of OA, beginning with Heberden's nodes, is itself a fascinating story. According to Albert Hoffa, R. Llewellyn Jones and Archibald Edward Garrod, the name OA was introduced in the mid-nineteenth century by surgeon Richard von Volkmann who distinguished it from rheumatoid arthritis and gout. Others preferred the terms 'chronical rheumatism', 'senile arthritis', 'hypertrophic arthritis' or 'arthritis deformans'. A similar narrative applies to the concept of OA affecting the whole joint vs the 'wear-and-tear' hypothesis, inflammation and the role of the central nervous system (CNS). In the late nineteenth and early twentieth centuries, the Garrods (father and son) and Hermann Senator argued that OA was a whole joint disease, and that inflammation played a major role in its progression. Garrod Jnr and John Spender also linked OA to a neurogenic lesion 'outside the joint'. The remaining twentieth century was no less dynamic, with major advances in basic science, diagnostics, treatments, surgical interventions and technologies. Today, OA is characterized as a multi-disease with inflammation, immune...Continue Reading

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Apr 1, 2020·JBJS Reviews·Kaushik HazratwalaConstantin E Dlaska
Jun 19, 2019·EFORT Open Reviews·Simon Donell
Jan 29, 2021·Arthritis Research & Therapy·Xiaoxia HaoTao Xu
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Aug 6, 2021·Orthopaedic Journal of Sports Medicine·Pooya TorkianReza Talaie
Nov 30, 2021·Arthritis & Rheumatology·Joel A Block

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