Defining the pupillary component of the perioculomotor preganglionic population within a unitary primate Edinger-Westphal nucleus.

Progress in Brain Research
P J MayJonathan T Erichsen

Abstract

The primate Edinger-Westphal nucleus (EW) contains perioculomotor preganglionic (pIII(PG)) motoneurons that control the lens and pupil. Separate subdivisions have been described in EW and termed visceral columns, with the lateral visceral column (lvc) reportedly receiving pretectal inputs for the pupillary light reflex. However, choline acetyl transferase staining reveals a single paired column of cells dorsal to the oculomotor nucleus, suggesting the EW is not subdivided. We investigated this issue by transneuronal retrograde labelling of pIII(PG) neurons in three monkey species. In all three, pIII(PG) neurons were contained in a single column. We have also examined which part of the macaque pIII(PG) population receives pretectal input. Injections of biocytin into the pretectum anterogradely labelled terminals that lay in close association with pIII(PG) motoneurons retrogradely labelled by ciliary ganglion injections of WGA-HRP. These close associations were concentrated in the ventromedial portion of the middle third of EW, suggesting this pIII(PG) region mediates pupillary control. In other cases, pretectal WGA-HRP injections, in addition to labelling terminals in the EW, produced a circular field of labelled neurons, and te...Continue Reading

Citations

Jul 28, 2012·Investigative Ophthalmology & Visual Science·Jonathan T Erichsen, Paul J May
Nov 20, 2016·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Hae Kwan ParkWonil Joo
Aug 21, 2014·PloS One·Mariska E KretTetsuro Matsuzawa
Jul 31, 2013·The Journal of Comparative Neurology·Jonathan T ErichsenPaul J May
Dec 19, 2019·Brain Structure & Function·Paul J May, Susan Warren
Nov 30, 2015·Brain Structure & Function·Paul J MayAnja K E Horn
Mar 30, 2018·Frontiers in Neural Circuits·Rylan S Larsen, Jack Waters
Dec 18, 2012·Anatomical Science International·Zdravko VitoševićMilan Milisavljević
Dec 26, 2019·Brain Structure & Function·Paul J MayJonathan T Erichsen
Apr 1, 2011·The Journal of Comparative Neurology·Tamás KoziczAndrey E Ryabinin
Oct 6, 2018·Scientific Reports·Marion QuirinsLionel Naccache
Aug 4, 2009·Annals of the New York Academy of Sciences·Anja K E HornSusanne Radtke-Schuller

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