Defining the Role of Estrogen Receptor β in the Regulation of Female Fertility

Endocrinology
M A Karim RumiMichael J Soares

Abstract

Estrogens are essential hormones for the regulation of fertility. Cellular responses to estrogens are mediated by estrogen receptor α (ESR1) and estrogen receptor β (ESR2). In mouse and rat models, disruption of Esr1 causes infertility in both males and females. However, the role of ESR2 in reproductive function remains undecided because of a wide variation in phenotypic observations among Esr2-mutant mouse strains. Regulatory pathways independent of ESR2 binding to its cognate DNA response element have also been implicated in ESR2 signaling. To clarify the regulatory roles of ESR2, we generated two mutant rat models: one with a null mutation (exon 3 deletion, Esr2ΔE3) and the other with an inframe deletion selectively disrupting the DNA binding domain (exon 4 deletion, Esr2ΔE4). In both models, we observed that ESR2-mutant males were fertile. ESR2-mutant females exhibited regular estrous cycles and could be inseminated by wild-type (WT) males but did not become pregnant or pseudopregnant. Esr2-mutant ovaries were small and differed from WT ovaries by their absence of corpora lutea, despite the presence of follicles at various stages of development. Esr2ΔE3- and Esr2ΔE4-mutant females exhibited attenuated preovulatory gonadotro...Continue Reading

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Citations

Feb 14, 2018·Biology of Reproduction·Rex A Hess, Paul S Cooke
Jun 15, 2018·Endocrine Reviews·Sylvia C Hewitt, Kenneth S Korach
Oct 3, 2018·Endocrinology·V Praveen ChakravarthiM A Karim Rumi
Mar 7, 2020·Endocrinology·V Praveen ChakravarthiM A Karim Rumi
Dec 15, 2019·Scientific Reports·Deepali C SenguptaElizabeth M Quinlan
Mar 15, 2018·Journal of Assisted Reproduction and Genetics·Adam J KriegKatherine F Roby
Nov 10, 2020·Heliyon·Carla MacheroniCatarina Segreti Porto
Dec 4, 2019·Data in Brief·V Praveen ChakravarthiM A Karim Rumi
Apr 25, 2019·Data in Brief·Vincentaben KhristiM A Karim Rumi
Jan 1, 2021·International Journal of Endocrinology·Fangui Zhao, Wenjun Wang
Feb 17, 2021·Molecular and Cellular Endocrinology·V Praveen ChakravarthiM A Karim Rumi
Mar 8, 2021·Molecular and Cellular Endocrinology·V Praveen ChakravarthiM A Karim Rumi
Dec 9, 2020·Molecular Aspects of Medicine·Camilla H K Hughes, Bruce D Murphy

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