Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics.

Oncogene
G L Semenza

Abstract

Adaptation of cancer cells to their microenvironment is an important driving force in the clonal selection that leads to invasive and metastatic disease. O2 concentrations are markedly reduced in many human cancers compared with normal tissue, and a major mechanism mediating adaptive responses to reduced O2 availability (hypoxia) is the regulation of transcription by hypoxia-inducible factor 1 (HIF-1). This review summarizes the current state of knowledge regarding the molecular mechanisms by which HIF-1 contributes to cancer progression, focusing on (1) clinical data associating increased HIF-1 levels with patient mortality; (2) preclinical data linking HIF-1 activity with tumor growth; (3) molecular data linking specific HIF-1 target gene products to critical aspects of cancer biology and (4) pharmacological data showing anticancer effects of HIF-1 inhibitors in mouse models of human cancer.

References

Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L WangG L Semenza
Jan 20, 1995·The Journal of Biological Chemistry·G L Wang, G L Semenza
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·P H MaxwellP J Ratcliffe
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·J YuB Vogelstein
May 23, 2000·Critical Reviews in Biochemistry and Molecular Biology·G L Semenza
Mar 21, 2002·Nature Reviews. Cancer·Adrian L Harris
Jun 8, 2002·The Journal of Biological Chemistry·Jennifer S IsaacsLeonard M Neckers
Jul 20, 2002·International Journal of Radiation Oncology, Biology, Physics·Michael I KoukourakisAdrian L Harris
May 10, 2003·International Journal of Radiation Oncology, Biology, Physics·Philipp BurriGünther Gruber
May 17, 2003·Science·Monica Garcia-BarrosRichard Kolesnick
Sep 6, 2003·Cancer Cell·James B BrugarolasWilliam G Kaelin
Dec 24, 2003·PLoS Biology·Keiichi KondoWilliam G Kaelin
Feb 18, 2004·Nature Reviews. Cancer·Ugo Cavallaro, Gerhard Christofori
Apr 6, 2004·Methods in Enzymology·Peter VaupelMichael Höckel
Jun 2, 2004·Nature Reviews. Cancer·Robert S Kerbel, Barton A Kamen
Jun 9, 2004·International Journal of Cancer. Journal International Du Cancer·Daniel E B SwinsonKenneth J O'Byrne
Jun 17, 2004·Journal of the National Cancer Institute·Oliver StoeltzingLee M Ellis
Aug 3, 2004·Nature Medicine·Bert Vogelstein, Kenneth W Kinzler
Dec 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexandra GiatromanolakiEfthimios Sivridis
Jan 25, 2005·Cardiovascular Research·Gilles Pagès, Jacques Pouysségur
Apr 26, 2005·International Journal of Cancer. Journal International Du Cancer·Jean-Philippe DalesColette Charpin

❮ Previous
Next ❯

Citations

Jan 11, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Carmen Chak-Lui WongGregg L Semenza
Dec 25, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jens M PothHolger K Eltzschig
Aug 13, 2013·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiaoli XuQidong You
Jul 3, 2013·Seminars in Cancer Biology·Séverine LorinPatrice Codogno
Oct 29, 2011·Journal of Medicinal Chemistry·Suazette Reid MooringBinghe Wang
Mar 10, 2012·Cell Death and Differentiation·M DemariaV Poli
Jan 13, 2012·Cell Death & Disease·C Muñoz-PinedoJ-E Ricci
Mar 4, 2011·Cell Death & Disease·I GucciniF Malisan
Oct 5, 2010·Nature Cell Biology·Dan S Kaufman
Dec 16, 2011·Nature Reviews. Cancer·Brian KeithM Celeste Simon
Nov 26, 2010·Nature Structural & Molecular Biology·Li-Jun DiKevin Gardner
May 18, 2011·Prostate Cancer and Prostatic Diseases·E S Antonarakis, A J Armstrong
Feb 18, 2011·The New England Journal of Medicine·Holger K Eltzschig, Peter Carmeliet
Aug 13, 2011·The New England Journal of Medicine·Gregg L Semenza
Sep 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Chapman M WrightMarc Ostermeier
Sep 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Carmen Chak-Lui WongGregg L Semenza
Dec 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Janet M TseLance L Munn
Nov 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Weibo LuoGregg L Semenza
Apr 17, 2013·Proceedings of the National Academy of Sciences of the United States of America·Paulina KucharzewskaMattias Belting
Jan 6, 2012·The Journal of Biological Chemistry·Maimon E HubbiGregg L Semenza
Sep 4, 2010·Antioxidants & Redox Signaling·Domenico Del PrincipeMaria Valeria Catani
Apr 5, 2011·Antioxidants & Redox Signaling·Yuxing ZhangJi Zhang
Sep 21, 2011·Antioxidants & Redox Signaling·Elisa GiannoniPaola Chiarugi
Dec 19, 2012·Antioxidants & Redox Signaling·Tiago R FigueiraAnibal E Vercesi
Jul 14, 2012·Carcinogenesis·Anatoliy SamoylenkoLyudmyla Drobot
Nov 28, 2012·International Immunology·Elena RiboldiAntonio Sica
Aug 14, 2013·Journal of the National Cancer Institute·Ivana JochmanováKarel Pacak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Kangae LeeG L Semenza
Journal of Cellular and Molecular Medicine
Barbara OnnisGiovanni Melillo
Proceedings of the National Academy of Sciences of the United States of America
G L WangG L Semenza
© 2022 Meta ULC. All rights reserved