Defining the Role of Icosapent Ethyl in Clinical Practice.

American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions
Subhankar ChatterjeePrakash Deedwania

Abstract

The health benefit of fish oil, i.e. omega-3 fatty acids (ω-3 FA) has a long history of debate. While there are a number of medications to reduce serum triglyceride levels, none have shown unanimous cardiovascular (CV) benefits. The most recent Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial (REDUCE-IT) assessing the CV outcome of one highly purified prescription ω-3 FA has certainly rejuvenated the debate. While this trial has been regarded as one of the most important landmark trials in preventive cardiology, the tolerability issue in a very high dose (4 g/day, as administered in the trial) is still a matter of concern. This article summarizes the current status and future perspective of icosapent ethyl in clinical practice in light of REDUCE-IT.

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Citations

Jul 1, 2021·Journal of Cardiovascular Pharmacology and Therapeutics·Dhiren Patel, Robert Busch

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