Defining the role of neoadjuvant systemic therapy in high-risk retroperitoneal sarcoma: A multi-institutional study from the Transatlantic Australasian Retroperitoneal Sarcoma Working Group.

Cancer
William W TsengAlessandro Gronchi

Abstract

In patients with retroperitoneal sarcoma (RPS), the incidence of recurrence after surgery remains high. Novel treatment approaches are needed. This retrospective study evaluated patients with primary, high-risk RPS who received neoadjuvant systemic therapy followed by surgery to 1) determine the frequency and potential predictors of radiologic tumor responses and 2) assess clinical outcomes. Clinicopathologic data were collected for eligible patients treated at 13 sarcoma referral centers from 2008 to 2018. Univariable and multivariable logistic models were performed to assess the association between clinical predictors and response. Overall survival (OS) and crude cumulative incidences of local recurrence and distant metastasis were compared. Data on 158 patients were analyzed. A median of 3 cycles of neoadjuvant systemic therapy (interquartile range, 2-4 cycles) were given. The regimens were mostly anthracycline based; however, there was significant heterogeneity. No patients demonstrated a complete response, 37 (23%) demonstrated a partial response (PR), 88 (56%) demonstrated stable disease, and 33 (21%) demonstrated progressive disease (PD) according to the Response Evaluation Criteria in Solid Tumors, version 1.1. Only a h...Continue Reading

References

May 1, 1989·Statistics in Medicine·S Durrleman, R Simon
Aug 1, 1996·Controlled Clinical Trials·M Schemper, T L Smith
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D C LinehanM F Brennan
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Nov 1, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A ItalianoB Bui
Feb 9, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alessandro GronchiPiero Picci
Aug 8, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J T MiuraK K Turaga
Nov 11, 2015·Journal of the National Comprehensive Cancer Network : JNCCN·Sujana MovvaElizabeth Handorf
Nov 3, 2016·Annals of Surgical Oncology·William W TsengAlessandro Gronchi
May 17, 2017·Current Opinion in Oncology·Winan J van HoudtRobin L Jones
Nov 12, 2017·Journal of Surgical Oncology·Piotr L Rutkowski, John T Mullen
Nov 12, 2017·Journal of Surgical Oncology·William W TsengAlessandro Gronchi
Dec 2, 2017·Journal of Surgical Oncology·Anastasia Constantinidou, Robin L Jones
Feb 13, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·UNKNOWN Trans-Atlantic Retroperitoneal Sarcoma Working Group (TARPSWG)
Feb 24, 2018·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L Max AlmondAnant Desai
Jun 5, 2019·Expert Review of Anticancer Therapy·Brittany DingleyAlessandro Gronchi
May 19, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alessandro GronchiPaolo Giovanni Casali

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Citations

Apr 5, 2021·Surgery·Ferdinando Carlo Maria CananziAlessandro Gronchi
Apr 22, 2021·Current Opinion in Oncology·Dario CallegaroAlessandro Gronchi
Jul 3, 2021·Current Treatment Options in Oncology·Miranda B LamThomas F DeLaney

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