Defining the vaccination window for respiratory syncytial virus (RSV) using age-seroprevalence data for children in Kilifi, Kenya.

PloS One
Joyce Uchi NyiroD J Nokes

Abstract

Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract disease in early life and a target for vaccine prevention. Data on the age-prevalence of RSV specific antibodies will inform on optimizing vaccine delivery. Archived plasma samples were randomly selected within age strata from 960 children less than 145 months of age admitted to Kilifi County Hospital pediatric wards between 2007 and 2010. Samples were tested for antibodies to RSV using crude virus IgG ELISA. Seroprevalence (and 95% confidence intervals) was estimated as the proportion of children with specific antibodies above a defined cut-off level. Nested catalytic models were used to explore different assumptions on antibody dynamics and estimate the rates of decay of RSV specific maternal antibody and acquisition of infection with age, and the average age of infection. RSV specific antibody prevalence was 100% at age 0-<1month, declining rapidly over the first 6 months of life, followed by an increase in the second half of the first year of life and beyond. Seroprevalence was lowest throughout the age range 5-11 months; all children were seropositive beyond 3 years of age. The best fit model to the data yielded estimates for the rate of inf...Continue Reading

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Citations

May 18, 2018·Human Vaccines & Immunotherapeutics·Jorge C G BlancoStefanie N Vogel
Oct 9, 2019·Influenza and Other Respiratory Viruses·Richard PebodyWenqing Zhang
May 17, 2018·Nature Communications·Jorge C G BlancoTrudy G Morrison
Mar 20, 2020·Science Translational Medicine·Simon B DrysdaleCharles J Sande
Feb 13, 2021·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Ania ZylbersztejnPia Hardelid
Dec 29, 2020·Frontiers in Bioengineering and Biotechnology·Teresia W MainaJodi L McGill
Feb 27, 2021·European Journal of Pediatrics·Mari D TakashimaRobert S Ware
Apr 28, 2021·Scientific Reports·Stijn P AndewegMichiel van Boven
Sep 23, 2021·Pediatric Pulmonology·Mari D TakashimaRobert S Ware

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Methods Mentioned

BETA
ELISA

Software Mentioned

Matlab
STATA

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