Defining trained immunity and its role in health and disease.

Nature Reviews. Immunology
Mihai G NeteaEicke Latz

Abstract

Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed 'trained immunity', a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define 'trained immunity' as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.

References

Nov 1, 1992·Scandinavian Journal of Immunology·J W van 't WoutR van Furth
Jan 1, 1988·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·F BistoniA Cassone
Mar 17, 2000·Immunological Reviews·R Medzhitov, C Janeway
May 23, 2000·Nature·A Purvis, A Hector
Mar 18, 2005·Annual Review of Immunology·Lewis L Lanier
Mar 31, 2005·Trends in Immunology·Joachim Kurtz
Oct 4, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·David R HodgeWilliam L Farrar
Feb 25, 2006·Cell·Max D Cooper, Matthew N Alder
May 18, 2007·Nature·Erik S BartonHerbert W Virgin
Jun 1, 2007·Nature·Simmie L FosterRuslan Medzhitov
Jun 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew B B McCallRobert W Sauerwein
Sep 1, 1891·Annals of Surgery·W B Coley
Nov 21, 2007·Microbes and Infection·D M E BowdishS Gordon
Feb 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul A MeyersUNKNOWN Children's Oncology Group
Aug 30, 2008·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·David B Levine
Jan 13, 2009·Nature·Joseph C SunLewis L Lanier
Feb 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Megan A CooperWayne M Yokoyama
Apr 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ryan M O'ConnellDavid Baltimore
Jan 12, 2010·The Journal of Allergy and Clinical Immunology·Francisco A Bonilla, Hans C Oettgen
Jul 21, 2010·Infection and Immunity·Natalia MuñozJosé A Chabalgoity
Dec 22, 2010·The Journal of Experimental Medicine·Niklas K BjörkströmHans-Gustaf Ljunggren
Jan 8, 2011·Science·Eric VivierSophie Ugolini
May 17, 2011·Advances in Immunology·Masayuki HiranoMax D Cooper
May 18, 2011·Cell Host & Microbe·Mihai G NeteaJos W M van der Meer
Aug 27, 2011·Nature Reviews. Immunology·Joseph C Sun, Lewis L Lanier
Nov 5, 2011·Expert Review of Anticancer Therapy·John H Stewart, Edward A Levine
Jan 21, 2012·Journal of Cellular Physiology·Dallas R Donohoe, Scott J Bultman

❮ Previous
Next ❯

Citations

May 8, 2020·EMBO Molecular Medicine·Masayuki Miyasaka
May 22, 2020·European Journal of Immunology·Virgil Schijns, Ed C Lavelle
Jun 19, 2020·Cancers·Lorey K SmithKaren E Sheppard
May 30, 2020·Mucosal Immunology·Alain Fischer
May 16, 2020·Indian Journal of Pediatrics·Nitin DhochakRakesh Lodha
Jun 20, 2020·Médecine sciences : M/S·Dylan JuckelSandrine Belouzard
Aug 18, 2020·Cellular & Molecular Immunology·Zhulang ChuYong Zhao
Aug 9, 2020·International Immunology·Ozlem BulutMihai G Netea
Sep 10, 2020·The New England Journal of Medicine·Alberto Mantovani, Mihai G Netea
Sep 10, 2020·Cellular Microbiology·Adeline Peignier, Dane Parker
Aug 30, 2020·The Indian Journal of Medical Research·Nasreen Zafar EhteshamSeyed Ehtesham Hasnain
Sep 24, 2020·American Journal of Human Biology : the Official Journal of the Human Biology Council·Sreedhar Chinnaswamy
Sep 8, 2020·Allergy·Désirée E Larenas-Linnemann, Fernanda Rodríguez-Monroy
Oct 3, 2020·Molecular Neurobiology·Gabriela Cruz-Carrillo, Alberto Camacho-Morales
May 14, 2020·AIDS Research and Therapy·Jing OuyangJean-Pierre Routy
Jul 18, 2020·Nature Reviews. Urology·Jelmer H van PuffelenSita H Vermeulen
May 16, 2020·Indian Journal of Pediatrics·Nitin DhochakRakesh Lodha
Oct 6, 2020·Frontiers in Public Health·Víctor M Martínez-TaboadaJosé L Hernández
Aug 6, 2020·Frontiers in Pharmacology·Siya Kamat, Madhuree Kumari
Oct 3, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Xiang ZhengRajkumar Savai
Aug 12, 2020·Proceedings of the National Academy of Sciences of the United States of America·Harindra D SathkumaraAndreas Kupz
Sep 23, 2020·Vaccines·Hidetaka Yakura
Oct 1, 2020·Proceedings of the National Academy of Sciences of the United States of America·Cecilia S Lindestam ArlehamnBjoern Peters
May 29, 2020·Nature Reviews. Immunology·Peter AabyFrank Shann
Sep 4, 2020·Cellular & Molecular Immunology·Jezabel VaradéÁfrica González-Fernández
Jul 29, 2020·Diagnostics·Wolfgang G K Müller-Lierheim
Oct 6, 2020·Frontiers in Immunology·Yi-Wei FengGuang-Qing Xu
Sep 6, 2020·Nature Reviews. Immunology·Mangalakumari JeyanathanZhou Xing
Jun 7, 2020·Science Immunology·Mark RoschewskiWyndham H Wilson
Sep 2, 2020·Current Opinion in Gastroenterology·Alberto Caminero, M I Pinto-Sanchez
Aug 28, 2020·The British Journal of Nutrition·Ana Heloneida de Araújo MoraisThaís Sousa Passos
Sep 28, 2020·Parasite Immunology·Kelvin Mokaya AbugaJulius Clemence R Hafalla
Oct 20, 2020·Frontiers in Immunology·Melanie R NeelandRichard Saffery
Oct 21, 2020·Vaccines·Iván Martínez-BazJesús Castilla
Oct 23, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Helin TercanSiroon Bekkering
May 29, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chao YanKui-Yang Zheng

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation
Hi-C
immunoprecipitation

Software Mentioned

Hi

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cell Host & Microbe
Mihai G Netea, Jos W M van der Meer
Nature Reviews. Drug Discovery
Willem J M MulderMihai G Netea
Immunological Reviews
Simone J C F M MoorlagMihai G Netea
Seminars in Immunology
Rob J W ArtsMihai G Netea
The Journal of Clinical Investigation
Shabaana A KhaderBill and Melinda Gates Foundation Collaboration for TB Vaccine Discovery Innate Immunity Working Group18
© 2021 Meta ULC. All rights reserved