Definition and management of anemia in patients infected with hepatitis C virus

Liver International : Official Journal of the International Association for the Study of the Liver
John G McHutchisonDan L Longo

Abstract

Chronic infection with hepatitis C virus (HCV) can progress to cirrhosis, hepatocellular carcinoma, and end-stage liver disease. The current best treatment for HCV infection is combination therapy with pegylated interferon and ribavirin. Although this regimen produces sustained virologic responses (SVRs) in approximately 50% of patients, it can be associated with a potentially dose-limiting hemolytic anemia. Hemoglobin concentrations decrease mainly as a result of ribavirin-induced hemolysis, and this anemia can be problematic in patients with HCV infection, especially those who have comorbid renal or cardiovascular disorders. In general, anemia can increase the risk of morbidity and mortality, and may have negative effects on cerebral function and quality of life. Although ribavirin-associated anemia can be reversed by dose reduction or discontinuation, this approach compromises outcomes by significantly decreasing SVR rates. Recombinant human erythropoietin has been used to manage ribavirin-associated anemia but has other potential disadvantages. Viramidine, a liver-targeting prodrug of ribavirin, has the potential to maintain the virologic efficacy of ribavirin while decreasing the risk of hemolytic anemia in patients with c...Continue Reading

References

Jan 1, 1991·Kidney International·J T MarshA R Nissenson
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M KusunokiH Abe
Apr 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D A RevickiR L Benz
Feb 1, 1993·The American Journal of Medicine·C S Kitchens
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L De FranceschiR Corrocher
Jul 25, 2000·Lancet·J L Spivak
Oct 14, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F Valderrábano
Feb 24, 2001·Journal of Hepatology·J G McHutchisonUNKNOWN Hepatitis Interventional Therapy Group
Oct 30, 2001·The New England Journal of Medicine·W C WuH M Krumholz
Sep 27, 2002·The New England Journal of Medicine·Michael W FriedJian Yu
Oct 3, 2002·Gastroenterology·John G McHutchisonUNKNOWN International Hepatitis Interventional Therapy Group
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Martin SchaeferKlaus Loeschke
Aug 9, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Douglas T Dieterich, Jerry L Spivak
Oct 29, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mark S Sulkowski
Mar 5, 2004·Annals of Internal Medicine·Stephanos J HadziyannisUNKNOWN PEGASYS International Study Group
Apr 2, 2004·Gastroenterology·Mitchell L ShiffmanUNKNOWN Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis Trial Group
May 12, 2004·Critical Care Clinics·Paul C HébertLing Qun Hu
May 21, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D CellaX Xu
Jul 3, 2004·Journal of Clinical Gastroenterology·Hariprasad S Trivedi, Madhuri Trivedi
Jul 13, 2004·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Mahmut TobuJawed Fareed
Aug 18, 2004·Current Opinion in Hematology·Tomas Ganz
Oct 2, 2004·European Journal of Haematology·L NiggE B Bachli
Oct 2, 2004·The New England Journal of Medicine·Charles L BennettNicole Casadevall
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul J PockrosUNKNOWN PROACTIVE Study Group
Jan 26, 2005·The American Journal of Gastroenterology·Vijayan BalanUNKNOWN HCV Natural History Study Group
Mar 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brennan M R SpiegelFasiha Kanwal
Jun 3, 2005·The American Journal of Gastroenterology·R Todd StravitzMitchell L Shiffman
Nov 19, 2005·The Journal of Antimicrobial Chemotherapy·Robert G Gish

❮ Previous
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Citations

Jul 24, 2010·European Journal of Clinical Pharmacology·Gaetano BertinoSergio Neri
Apr 13, 2007·AIDS Patient Care and STDs·Jaydeep S Kadam, Andrew H Talal
Jul 22, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Eleanor L Ramos
Sep 30, 2009·World Journal of Gastroenterology : WJG·Rosario Gonzalez-CasasRicardo Moreno-Otero
Jan 1, 2010·Mediterranean Journal of Hematology and Infectious Diseases·Paola MancinoJacopo Vecchiet
Oct 1, 2011·Clinical Journal of Gastroenterology·Andrew J SkabelundKevin J Goist
May 19, 2007·Journal of Hepatology·Yves Benhamou
Jul 9, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yves BenhamouPaul J Pockros
Jul 16, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michela GiustoMarina Berenguer
Mar 2, 2012·Pediatrics International : Official Journal of the Japan Pediatric Society·Mitsuyoshi SuzukiToshiaki Shimizu
Oct 15, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·James F CrismaleAndrea D Branch
Apr 12, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Rui HuangChao Wu
Apr 18, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Haiyan GuoYanjiao Wang
Dec 17, 2014·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Ehab F Mostafa, Asmaa N Mohammad
Feb 3, 2015·Regulatory Toxicology and Pharmacology : RTP·Jeong-Hwan CheByeong-Cheol Kang
Jun 2, 2016·Pharmacogenomics·Antonio D'AvolioGiovanni Di Perri
Feb 7, 2013·The Annals of Pharmacotherapy·Lauren M Hynicka, Emily L Heil
Apr 3, 2007·The American Journal of Gastroenterology·John G McHutchisonJohn B Wong
Jun 30, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sammy SaabRonald W Busuttil
Oct 5, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masatoshi IshigamiHidemi Goto
Jul 1, 2009·Expert Opinion on Pharmacotherapy·Angelo Iacobellis, Angelo Andriulli
May 23, 2019·Journal of Clinical Laboratory Analysis·Lingyan LiuJie Xu
Oct 1, 2019·European Journal of Gastroenterology & Hepatology·Omaima Mahmoud AbbasAsmaa Said Atta
Jan 17, 2017·Gastroenterology Research and Practice·Qitian HeZhifu Wei
Feb 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair YounossiJohn Kincaid
Mar 22, 2021·Gastrointestinal Endoscopy Clinics of North America·Alexander Ross RobertsonMarco Pennazio

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