Definition and Management of Positive Margins for Invasive Breast Cancer

The Surgical Clinics of North America
Apoorve NayyarKandace P McGuire

Abstract

Breast-conserving surgery (BCS) followed by radiation therapy is the current standard of care for early stage breast cancer. Successful BCS necessitates complete tumor resection with clear margins at the pathologic assessment of the specimen ("no ink on tumor"). The presence of positive margins warrants additional surgery to obtain negative final margins, which has significant physical, psychological, and financial implications for the patient. The challenge lies in developing accurate real-time intraoperative margin assessment techniques to minimize the presence of "ink on tumor" and the subsequent need for additional surgery.

Citations

Dec 11, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Nicholas E WojtynekAaron M Mohs
Jun 7, 2019·Journal of Surgical Oncology·Beiqun ZhaoSarah L Blair
Mar 24, 2021·Scientific Reports·Ragini KothariMichael C Storrie-Lombardi
Apr 20, 2021·The American Surgeon·Catherine Sarre-LazcanoHeriberto Medina-Franco

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