PMID: 18400849DOI: 10.1128/jvi.02475-07Apr 11, 2008Paper
Definition of a conserved immunodominant domain on hepatitis C virus E2 glycoprotein by neutralizing human monoclonal antibodies.
Journal of Virology
Zhen-yong KeckSteven K H Foung
Abstract
Development of a successful hepatitis C virus (HCV) vaccine requires the definition of neutralization epitopes that are conserved among different HCV genotypes. Five human monoclonal antibodies (HMAbs) are described that cross-compete with other antibodies to a cluster of overlapping epitopes, previously designated domain B. Each HMAb broadly neutralizes retroviral pseudotype particles expressing HCV E1 and E2 glycoproteins, as well as the infectious chimeric genotype 1a and genotype 2a viruses. Alanine substitutions of residues within a region of E2 involved in binding to CD81 showed that critical E2 contact residues involved in the binding of representative antibodies are identical to those involved in the binding of E2 to CD81.
References
Apr 1, 1996·The Journal of Infectious Diseases·K KrawczynskiD A Carson
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·D RosaS Abrignani
Oct 24, 2000·Journal of Virology·K G HadlockS K Foung
Jul 5, 2002·Journal of Virology·Reginald F ClaytonArvind H Patel
May 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mayla HsuJane A McKeating
Nov 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Birke BartoschRobert H Purcell
Aug 17, 2004·Journal of Virology·Zhen-Yong KeckSteven K H Foung
Apr 29, 2005·Journal of Virology·Dimitri LavilletteFrançois-Loïc Cosset
Jun 16, 2005·Journal of Virology·Anne GoffardJean Dubuisson
Oct 18, 2005·Journal of Virology·Zhen-Yong KeckSteven K H Foung
Oct 29, 2005·Journal of Virology·Zhaohui CaiGuangxiang Luo
Jan 28, 2006·Journal of Virology·Donna M TscherneCharles M Rice
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·MinKyung YiStanley M Lemon
Aug 17, 2006·Journal of Virology·Ania M OwsiankaJonathan K Ball
Nov 3, 2006·Journal of Virology·MinKyung YiStanley M Lemon
Nov 3, 2006·Journal of Virology·Zhen-Yong KeckSteven K H Foung
Mar 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jan M PestkaThomas F Baumert
May 18, 2007·Journal of Virology·Emilia FalkowskaTatjana Dragic
Oct 4, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel X JohanssonMats A A Persson
Oct 5, 2007·Cellular and Molecular Life Sciences : CMLS·F Helle, J Dubuisson
Nov 9, 2007·Journal of Virology·Mario PerottiRoberto Burioni
Dec 8, 2007·Nature Medicine·Mansun LawDennis R Burton
Feb 15, 2008·The Journal of General Virology·Ania M OwsiankaArvind H Patel
❮ Previous
Next ❯
Citations
Dec 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Meital Gal-TanamyStanley M Lemon
Apr 12, 2012·Proceedings of the National Academy of Sciences of the United States of America·Erick GiangMansun Law
May 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Leopold KongMansun Law
May 5, 2009·The Journal of Biological Chemistry·Sibylle HaidEve-Isabelle Pécheur
Oct 18, 2011·The Journal of Biological Chemistry·Yong WangSteven K H Foung
Jul 17, 2012·Science·Dennis R BurtonIan A Wilson
Mar 27, 2009·Journal of Virology·Zhen-yong KeckSteven K H Foung
May 6, 2011·Journal of Virology·Michelle C SaboMichael S Diamond
May 25, 2012·Journal of Virology·Rebecca R GrayMarco Salemi
Oct 3, 2008·Journal of Virology·Joe GroveJane A McKeating
Oct 22, 2010·Journal of Virology·Claire L BrimacombeJane A McKeating
Oct 26, 2012·Journal of Virology·Zhenyong KeckSteven K H Foung
Sep 21, 2012·Journal of Virology·Jane A PotterArvind H Patel
Mar 20, 2010·Journal of Virology·Simrat DhillonArvind H Patel
Apr 2, 2010·Journal of Virology·Dorothea BankwitzThomas Pietschmann
Aug 5, 2011·Journal of Virology·Zhen-Yong KeckSteven K H Foung
Dec 16, 2011·Journal of Virology·Alexander W TarrJonathan K Ball
Jun 10, 2010·Virology Journal·Partha K ChandraSrikanta Dash
Dec 17, 2009·PloS One·Nicasio ManciniRoberto Burioni
Nov 3, 2011·PloS One·Pascal LapierreHugo Soudeyns
Jan 9, 2014·PloS One·Zhong ZhaoPei Zhang
Jul 10, 2010·PLoS Pathogens·Julia BitzegeioThomas Pietschmann
Apr 19, 2012·PLoS Pathogens·Zhen-yong KeckSteven K H Foung
Nov 10, 2011·Viruses·François HelleJean Dubuisson
Dec 14, 2011·Viruses·Yong WangSteven K H Foung
Dec 4, 2012·Viruses·Samira Fafi-KremerThomas F Baumert
Jan 17, 2013·Antiviral Therapy·Lynn B Dustin, Edgar D Charles
Apr 8, 2014·World Journal of Gastroenterology : WJG·Nora A FierroArturo Panduro
Feb 11, 2014·Viruses·Lucie FénéantLaurence Cocquerel
Mar 13, 2014·Viruses·Gabrielle VieyresThomas Pietschmann
Oct 11, 2013·Journal of Virology·Valentina D'ArienzoDenys Brand
Aug 18, 2012·Antiviral Research·Giuseppe SauttoRoberto Burioni
Sep 29, 2009·Gastroenterology·William O OsburnAndrea L Cox
Nov 15, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elodie BeaumontPhilippe Roingeard
Jul 22, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Thomas H R CarlsenJens Bukh
Jul 28, 2015·Biotechnology Journal·Ana F RodriguesAna S Coroadinha
Dec 3, 2014·Journal of Hepatology·Thomas F BaumertGeorg M Lauer
Dec 18, 2008·The Journal of General Virology·Jeroen WitteveldtArvind H Patel
Nov 4, 2011·The Journal of General Virology·Victoria C EdwardsJonathan K Ball
Mar 7, 2009·The Journal of General Virology·Michela E Burlone, Agata Budkowska
May 2, 2015·Current Opinion in Virology·Leopold KongMansun Law
Dec 15, 2010·Journal of Hepatology·Mirjam B ZeiselThomas F Baumert
Mar 4, 2014·Antiviral Research·Jonathan K BallJane A McKeating
Aug 15, 2014·PLoS Pathogens·Zhen-yong KeckSteven K H Foung
Jun 9, 2016·Expert Review of Vaccines·Catherine FauvelleThomas F Baumert
Jul 5, 2016·Journal of Virological Methods·L Earnest-SilveiraJ Torresi
May 6, 2016·The Journal of General Virology·L Earnest-SilveiraJoseph Torresi
Sep 23, 2016·Current Opinion in Virology·Brian G PierceSteven Kh Foung
Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Brian G PierceSteven K H Foung
Dec 21, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patricia T VietheerHeidi E Drummer
❮ Previous
Next ❯
Related Concepts
Related Feeds
Related Papers
The Journal of General Virology
Ania OwsiankaArvind H Patel
Proceedings of the National Academy of Sciences of the United States of America
Daniel X JohanssonMats A A Persson
Journal of Virology
Mario PerottiRoberto Burioni
Journal of Virology
Zhen-yong KeckSteven K H Foung
Journal of Virology
Zhen-Yong KeckSteven K H Foung