Definition of a new score for severity of generalized Neisseria meningitidis infection

European Journal of Pediatrics
W NürnbergerU Göbel

Abstract

Neisseria meningitidis infection may present as meningitis or as severe, fulminant sepsis. In order to classify individual patients early according to the expected course of the disease, we developed a score named Neisseria sepsis index [NESI]. The NESI was defined using the parameters heart rate, mean arterial blood pressure, base excess and presence of acute subcutaneous bleeding and/or skin necroses (minimal value [= no evidence for sepsis] NESI 0; maximum value [= most severe sepsis] NESI 8). Seventeen patients with documented, systemic N. meningitidis infection were prospectively assessed for the terminal complement complex (TCC), serum tumour necrosis factor alpha (TNF alpha) levels (as laboratory parameters for severity of sepsis) and NESI score. The evaluation was immediately performed when the patients were admitted to the hospital. The 17 patients showed the following distribution of data: NESI 0 (n = 4), NESI 1 (n = 6), NESI 2 (n = 0), NESI 3 (n = 1), NESI 4 (n = 2), NESI 5 (n = 2), NESI 6 (n = 0), NESI 7 (n = 1), NESI 8 (n = 1). Mortality was 4/17 patients, all had NESI > or = 5. TCC values ranged from 647-6461 ng/ml (normal range: 130-360 ng/ml); and was not correlated to NESI. TNF alpha values ranged from 10-910 p...Continue Reading

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Citations

Jun 24, 2010·Heart Failure Reviews·Petra KleinbongardGerd Heusch
Dec 29, 2007·The Journal of Pathology·J R Bradley
Feb 25, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Hyehun ChoiFred S Lamb
Jul 27, 2017·The FEBS Journal·Vladimir N UverskyElrashdy M Redwan
Jun 20, 2019·International Journal of Food Sciences and Nutrition·Qiaowen OuWeiqun Lin

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