PMID: 2510166Nov 1, 1989Paper

Definition of a population of CD4-8- T cells that express the alpha beta T-cell receptor and respond to interleukins 2, 3, and 4

Proceedings of the National Academy of Sciences of the United States of America
M LondeiM Feldmann

Abstract

Whereas most T cells express surface CD4 or CD8 molecules, a minority lacks both. CD4-8- cells usually express the gamma delta T-cell receptor, but here we describe a population of CD4-8- T cells from the peripheral blood that express the alpha beta heterodimer. These cells have different surface antigens than gamma delta+ T cells, expressing CD5 but lacking CD16, and differ in function from gamma delta+ T cells. CD4-8- alpha beta+ cells lack non-major histocompatibility complex-restricted cytolytic function but can be induced to lyse their target cells after activation of their T-cell receptors. A peculiar characteristic of these cells is their responsiveness to interleukin 3. Since these cells have not altered their phenotype or function over a 12-month period in culture, they appear to be mature T cells. The results indicate that normal human peripheral blood contains two subsets of CD4-8- T cells, expressing either gamma delta or alpha beta receptors, that differ in function, phenotype, and growth control.

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Citations

Sep 1, 1990·Research in Immunology·A MorettaL Moretta
Jun 1, 1994·Current Opinion in Immunology·I N Crispe
Oct 3, 2002·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·U JohanssonM Londei
Aug 14, 1999·Immunology·A TanegashimaT Fukunaga
Feb 16, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mei-Chuan HuangEdward J Goetzl
Dec 1, 1991·Clinical and Experimental Immunology·U ReinholdH W Kreysel
Sep 1, 1993·Clinical and Experimental Immunology·J G MurisonM Londei
Dec 1, 1991·Scandinavian Journal of Immunology·J Reimann
Oct 1, 1995·Immunological Reviews·R S BlumbergS P Balk
Feb 22, 2014·Orphanet Journal of Rare Diseases·Lisa Giovannini-ChamiUNKNOWN French Respirare® Group
Jan 1, 1993·Cancer Investigation·A Lindemann, R Mertelsmann
Jan 1, 1993·Cancer Investigation·A Ganser
Apr 11, 2001·American Journal of Clinical Pathology·E S CibasE N Allred
Jan 1, 1994·International Reviews of Immunology·Y MakinoM Taniguchi
Oct 17, 2001·American Journal of Clinical Pathology·S JamalS H Kroft
Feb 1, 1990·European Journal of Immunology·M LondeiM Feldmann

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