Definition of botulinum toxin failure in neurogenic detrusor overactivity: Preliminary results of the DETOX survey

Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
Benoit PeyronnetMembres du GENULF (Groupe d’étude de neuro-urologie de langue française) et du comité de neuro-urologie de l’AFU (Associatio

Abstract

There is currently no guideline regarding the management of neurogenic detrusor overactivity (NDO) refractory to intra-detrusor botulinum toxin injections. The primary objective of the present study was to find a consensus definition of failure of botulinum toxin intra-detrusor injections for NDO. The secondary objective was to report current trends in the managment of NDO refractory to botulinum toxin. A survey was created, based on data drawn from current literature, and sent via e-mail to all the experts form the Group for research in neurourology in french language (GENULF) and from the comittee of neurourology of the French urological association (AFU). The experts who did not answer to the first e-mail were contacted again twice. Main results from the survey are presented and expressed as numbers and proportions. Out of the 42 experts contacted, 21 responded to the survey. Nineteen participants considered that the definition of failure should be a combination of clinical and urodynamics criteria. Among the urodynamics criteria, the persistence of a maximum detrusor pressure>40 cm H2O was the most supported by the experts (18/21, 85%). According to the vast majority of participants (19/21, 90.5%), the impact of injections ...Continue Reading

References

Mar 27, 2009·Evidence-based Dentistry·Derek Richards
Nov 29, 2011·BJU International·Suzanne M BiersTamsin J Greenwell
Nov 28, 2012·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·S GailletG Karsenty

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Citations

May 11, 2018·The Journal of Urology·Benoit PeyronnetUNKNOWN GENULF and the AFU Committee of NeuroUrology
May 18, 2016·Neurourology and Urodynamics·Juliette HascoetUNKNOWN French Referral Network of Spina Bifida
Nov 19, 2019·European Urology Focus·Apostolos Apostolidis, Anne P Cameron

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