PMID: 6407985Jan 1, 1983Paper

Definition of four HLA-A2 subtypes by CML typing and biochemical analysis

Immunogenetics
J J van der PoelH L Ploegh

Abstract

The population of HLA-A2-positive individuals, currently considered serologically homogeneous, can be divided into three subtypes on the basis of antigen recognition by various HLA-A2-specific cytotoxic T lymphocytes (CTLs). When these three types of HLA-A2 antigens were analyzed biochemically, they were found to be distinct. Isoelectric focusing (IEF) of HLA antigens digested with neuraminidase (NANAse) suggested that the difference(s) reside in the polypeptide backbone of the HLA-A2 heavy chain. Biochemical analysis distinguishes three distinct categories of HLA-A2 antigens: (1) a major subtype, designated HLA-A2.I, (2) a minor subtype, designated HLA-A2.II, possessing a more basic isoelectric point (IEP) and (3) a minor HLA-A2 subtype more acidic in its IEP than HLA-A2.I, designated HLA-A2.III. A fourth HLA-A2 subtype could be defined by discordance between cell-mediated lympholysis (CML) typing and biochemical analysis. The latter HLA-A2 antigen was defined as a variant by CTL, but was biochemically indistinguishable from the major subtype HLA-A2.I.

References

Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L R PeaseS G Nathenson
Feb 1, 1983·Human Immunology·H H MöldersH L Ploegh

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Citations

Jan 1, 1987·Immunogenetics·L P de WaalC P Engelfriet
Jan 1, 1987·Immunogenetics·M S KruskallE J Yunis
Jan 1, 1985·Immunogenetics·S Y YangE J Yunis
Jan 1, 1984·Immunogenetics·E GoulmyJ J van Rood
Jan 1, 1988·Immunogenetics·R CastañoJ A López de Castro
Jul 1, 1989·Immunology Today·J A López de Castro
Oct 1, 1984·Human Immunology·A W HahnH L Ploegh
Apr 1, 1986·Human Immunology·F H ClaasJ J van Rood
Jul 1, 1986·Human Immunology·J J van der PoelJ J van Rood
Sep 1, 1987·Human Immunology·B D ClarkP I Terasaki
Jul 1, 1990·Human Immunology·A A FullerT C Fuller
Feb 1, 1990·Human Immunology·L ZhangF H Claas
Mar 1, 1992·Human Immunology·M A Fernandez-ViñaP Stastny
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M A VegaJ A López de Castro
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A J McMichaelJ L Strominger
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J Santos-AguadoJ L Strominger
Sep 1, 1990·The Journal of Experimental Medicine·J A FrelingerA J McMichael
Aug 1, 1994·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·C J DaviesP Horin
Dec 1, 1994·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·B S KubensH Grosse-Wilde
Dec 1, 1988·Annals of the Rheumatic Diseases·C T PeaseD A Brewerton
Apr 1, 1996·Immunology Today·M Browning, P Krausa
Jun 1, 1989·Journal of Immunogenetics·D I WatkinsN L Letvin
Sep 1, 1989·European Journal of Immunology·H EpsteinN Holmes
Jul 1, 1985·Immunological Reviews·J A Lopez de CastroJ L Strominger
Jan 1, 1989·Vox Sanguinis·I Doxiadis, H Grosse-Wilde
Mar 1, 1989·Tissue Antigens·A Hajek-RosenmayrM Kirnbauer
Sep 1, 1988·European Journal of Immunology·D I WatkinsN L Letvin

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