Definition of Mafa-A and -B haplotypes in pedigreed cynomolgus macaques (Macaca fascicularis).

Immunogenetics
N OttingRonald E Bontrop

Abstract

The major histocompatibility complex (MHC) class I B gene/allelic repertoire was investigated in a pedigreed population of cynomolgus macaques of mixed Indonesian/Malaysian origin. The Mafa-B alleles detected in this cohort are mostly specific for a given geographic area, and only a small number of alleles appears to be shared with other populations. This suggests the fast evolution of Mafa-B alleles due to adaptation to new environments. In contrast to humans, the B locus in Old World monkeys displays extensive copy number variation. The Mafa-B and previously defined -A gene combinations segregate in families and thus allowed the definition of extended haplotypes. In many cases it was possible to assign a particular Mafa-I allele to one of these Mafa-A/B haplotypes as well. The presence of a large number of stable haplotypes in this cohort of animals, which was pedigreed for up to eight generations, looks promising for developing discriminative MHC typing tools that are less cumbersome. Furthermore, the discovery of 53 unreported Mafa-B sequences expands the lexicon of alleles significantly, and may help in understanding the complex organisation of the macaque B region.

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Citations

Jul 20, 2010·Immunogenetics·Taeko K NaruseAkinori Kimura
Sep 2, 2011·Immunogenetics·Yusuke SaitoAkinori Kimura
Sep 21, 2013·Immunogenetics·Xiang YanZhaozeng Sun
Jul 14, 2010·Journal of Medical Primatology·Peter ParhamLisbeth A Guethlein
Aug 19, 2015·Immunological Reviews·Natasja G de GrootRonald E Bontrop
Apr 7, 2011·Veterinary Immunology and Immunopathology·Shirley A Ellis, Gemma Codner
Feb 27, 2018·Immunogenetics·Marit K H van der WielR E Bontrop
Aug 29, 2019·Cells·Takashi Shiina, Antoine Blancher

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Datasets Mentioned

BETA
FN546180

Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

TreeDyn
MacVector
PhyML
Sequence Navigator
phylogeny

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