PMID: 1266754May 1, 1976Paper

Definition of myocardial perfusion by continuous infusion of krypton-81m

The American Journal of Cardiology


Krypton-81m, a radionuclide emitting a 190 kev gamma ray, has a half-life of 13 seconds. It is a radioisotope of an inert water-soluble noble gas and is produced at a constant rate by spontaneous decay of rubidium-81 in an 81Rb-81mKr generator-delivery system. Delivery is through a minibore Teflon catheter that can be threaded through a standard no. 7 or 8F angiographic catheter. The generator is eluted by 5 percent dextrose-in-water, delivered by infusion pump at 1.5 ml/min, and the eluate is infused intraarterially directly into any organ. Delivery and decay reach equilibrium within 2 minutes, producing a heterogeneous distribution that is proportional to the perfusibility of the tissue concerned and the time required to reach it. The ultrashort halflife of the radionuclide rapidly eliminates activity when delivery ceases; thus, experiments can be sequentially repeated at brief intervals. The radiation hazard for easily imaged doses is negligible. Preliminary studies in open chest dogs were visualized by scintillation camera, stored on digital data disk, processed, and displayed in dual channel, dual color mode on a video system. Images of myocardial perfusion defined relative levels of perfusion, collateral circulation betwe...Continue Reading


Jan 1, 1975·International Journal of Nuclear Medicine and Biology·L W MayronJ E Gindler
Jul 1, 1975·International Journal of Nuclear Medicine and Biology·L W MayronJ E Gindler
Sep 1, 1973·Radiology·P V HarperH L Brooks
May 1, 1974·The International Journal of Applied Radiation and Isotopes·L W MayronJ E Gindler
Jun 1, 1970·Radiology·E E Christensen, F J Bonte
Jan 1, 1965·Circulation Research·J R EVANSJ C SPEARS


Mar 14, 2002·Nuclear Medicine Communications·H Anderson, P Price
May 1, 1986·Progress in Cardiovascular Diseases·D D MillerH W Strauss
Oct 1, 1976·International Journal of Nuclear Medicine and Biology·A L SwansonE Kaplan

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