Definition of reference ranges for β-isomerized carboxy-terminal telopeptide collagen type I for children and adolescents.

Journal of Pediatric Endocrinology & Metabolism : JPEM
Veronica C P de MeloCarlos E Dos S Ferreira

Abstract

Bone metabolism involves many complex pathways that are disturbed by several bone diseases. The literature shows some limitations concerning pediatric reference intervals to bone markers, mainly because of the low number of patients included in the studies, the heterogeneity of methods, beyond the fact that it is time-consuming and expensive. The aim of this study was to determine reference values for β-isomerized carboxy-terminal telopeptides collagen type I (β-CTX), a marker of bone resorption, for children and adolescents. Blood samples from 246 patients were collected and β-CTX was measured using an electrochemiluminescence immunoassay (ECLI). We propose reference ranges for β-CTX concentration from the 2.5 percentile and 97.5 percentile for each age group. The reference values obtained, concerning children and adolescents, might be useful in the evaluation of diseases such as osteosarcoma and anorexia in both childhood as adolescence.

References

Nov 5, 1999·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·M J Seibel, H W Woitge
Jan 21, 2006·Clinical Biochemistry·Liju Yang, Vijaylaxmi Grey
Apr 28, 2006·Pediatric Research·Elena RuzaAna Patiño-Garcia
Nov 16, 2006·The Journal of Clinical Endocrinology and Metabolism·Markus RauchenzaunerWolfgang Högler
Nov 19, 2010·Advances in Medical Sciences·J AmbroszkiewiczW Woźniak
Apr 6, 2011·European Journal of Endocrinology·Maria P YavropoulouJohn G Yovos
May 3, 2011·Clinical Biochemistry·Yun HuangVijaylaxmi Grey
Nov 6, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sara P WynessJoely A Straseski
Nov 8, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D HerrmannW Ahrens
Jul 3, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J M OlmosJ González-Macías
Jul 22, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Zeynep Gökçe Gayretli AydinPeyami Cinaz
Apr 14, 2016·Joint, Bone, Spine : Revue Du Rhumatisme·Laëtitia Michou, Philippe Orcel

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