PMID: 8939151Nov 1, 1996Paper

Definition of the human T-cell epitopes of Fel d 1, the major allergen of the domestic cat

The Journal of Allergy and Clinical Immunology
C M CounsellR D Garman

Abstract

A heterodimeric acidic glycoprotein (Fel d 1) has been defined as the major allergen of the domestic cat. Because T-cell help is required for the initiation and maintenance of allergic responses, it is of importance to determine the T-cell-reactive regions of the Fel d 1 molecule. Overlapping peptides corresponding to the two chains of Fel d 1 were tested in proliferation assays on polyclonal T-cell lines and for the ability to bind Fel d 1-specific IgE in ELISA and histamine release assays. Assay of T-cell lines derived from 53 subjects allergic to cats demonstrated that the majority of T-cell reactivity is found in chain 1 of Fel d 1. Two peptides (Fel-1 and Fel-2) containing major epitopes, alone or as a mixture, efficiently activated T cells and exhibited minimal detectable reactivity with IgE by ELISA or histamine release assay. Two Fel d 1 peptides containing major T-cell epitopes have been identified, have been shown to bind minimal Fel d 1-specific IgE, and are now being tested for the ability to decrease T-cell responses in patients with cat allergy as a new form of immunotherapy.

References

Apr 1, 1991·Molecular Immunology·O A DuffortM Lombardero
Jan 1, 1987·International Archives of Allergy and Applied Immunology·O DuffortM Lombardero
Sep 1, 1984·The Journal of Allergy and Clinical Immunology·J L OhmanK M Leitermann
Aug 1, 1984·The Journal of Allergy and Clinical Immunology·K Leitermann, J L Ohman
Dec 1, 1993·The Journal of Experimental Medicine·H SecristD T Umetsu

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Citations

Mar 15, 2002·Current Allergy and Asthma Reports·F Runa AliMark Larché
Jun 30, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Adrian G Letz, Christopher W Calabria
Aug 12, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Laurent Malherbe
Mar 18, 2011·The Journal of Allergy and Clinical Immunology·Katarzyna NiespodzianaRudolf Valenta
Feb 13, 2007·The Journal of Allergy and Clinical Immunology·Judith A Woodfolk
Jun 6, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E A L BatemanG S Ogg
Aug 15, 2006·Immunological Reviews·Dale T Umetsu, Rosemarie H DeKruyff
Jul 7, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L R CrackG S Ogg
May 23, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A ImmonenT Virtanen
Feb 12, 2015·The Journal of Allergy and Clinical Immunology·Claudia KitzmüllerBarbara Bohle
Mar 25, 2009·Allergology International : Official Journal of the Japanese Society of Allergology·Toshio SoneKohsuke Kino
Jun 2, 2010·The Journal of Allergy and Clinical Immunology·William W KwokDavid Robinson
Jan 8, 2011·The Journal of Allergy and Clinical Immunology·Margitta WormMark Larché
Dec 14, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P A WürtzenR J Van Neerven
Jun 26, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J VermaN Arora
Jan 29, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R J Van NeervenH Ipsen
Mar 24, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B BohleC Ebner
Jun 23, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T KinnunenT Virtanen
Mar 1, 2006·Expert Review of Clinical Immunology·Judith A Woodfolk
Sep 12, 2009·Current Opinion in Allergy and Clinical Immunology·Harold S Nelson
Mar 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C TexierB Maillère
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amanda J ReeferJudith A Woodfolk
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anu ImmonenTuomas Virtanen
May 19, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T SaarneM van Hage-Hamsten
Jan 18, 2018·Allergologia et immunopathologia·J P SolaM Peñalver-Mellado
Sep 12, 2001·Biochemistry·T L ColpittsS D Stroupe
Sep 25, 2021·Immunotherapy·Rashi RamchandaniAnne K Ellis

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