PMID: 9437789Jan 23, 1998Paper

Definition of the potentially fertile period from urinary steroid excretion rates. Part II. A threshold value for pregnanediol glucuronide as a marker for the end of the potentially fertile period in the human menstrual cycle

Steroids
Leonard F BlackwellDelwyn G Cooke

Abstract

Application of time series analysis to a database containing serial pregnanediol data from 113 complete ovulatory menstrual cycles contributed by 83 women of proven fertility and 68 cycles for which pregnanediol values were available over the ovulatory period, detected the first statistically significant risk in pregnanediol excretion for all cycles for which a baseline was available (n = 170). However, even at the 99% confidence level, for 22% of cycles a rise was observed before the presumed day of ovulation. Therefore, a threshold value for pregnanediol was sought from the database as a better marker for the end of fertility. A value of 1.4 mg per 24 h was not reached before day 2 after the pre-ovulatory estrogen peak day for 96% of the cycles. In the remaining 4% of cycles it was reached one day after the total estrogen peak day. The validity of this threshold was confirmed in extensive studies using the Ovarian Monitor where the equivalent is 6.3 mumol per 24 h of pregnanediol glucuronide and measurements are performed on timed urine specimens with a minimum collection time of three hours. These studies were as follows: 1) a World Health Organization study on the use of the Ovarian Monitor as a fertility self test in the h...Continue Reading

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Citations

Jan 1, 2001·Indian Journal of Clinical Biochemistry : IJCB·M DesaiM I Khatkhatay
May 3, 2003·Biochemical and Biophysical Research Communications·C Mark Smales, Leonard F Blackwell
Jul 4, 2002·Fertility and Sterility·María Elena Alliende
Dec 7, 2002·Obstetrics and Gynecology·Joseph B StanfordHarry Hatasaka
May 29, 2015·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Judith RoosChristian Gnoth
Jan 10, 2012·Contraception·Irit Sinai, Jeannette Cachan
Jul 27, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Stephen J Genuis, Thomas P Bouchard
May 30, 2006·Journal of Pediatric and Adolescent Gynecology·Pilar VigilHanna Klaus
May 12, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jirí SpacekMiroslav Förstl
Dec 21, 2017·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Lyliane RosettaRémy Slama
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·Mary Jane De SouzaBill L Lasley
Jul 5, 2018·The Linacre Quarterly·Leonard BlackwellSimon Brown
Nov 17, 1998·Bioconjugate Chemistry·C M SmalesL F Blackwell

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