PMID: 11932901Apr 5, 2002Paper

Definition of three minimal deleted regions by comprehensive allelotyping and mutational screening of FHIT,p16(INK4A), and p19(ARF) genes in nasopharyngeal carcinoma

Cancer
Jenq-Yuh KoYuh-Shan Jou

Abstract

Recurrent deletion on a chromosomal location in tumor cells can be detected by frequent allelic loss and generally is considered to be an indication of the existence of a tumor suppressor gene (TSG) in the region. In the current study, using fluorescent-labeled, high-density microsatellite markers for allelotyping, the authors pinpointed three minimal deleted regions (MDRs) and screened mutations of putative TSGs on chromosomes 3, 9, and 11 in nasopharyngeal carcinoma (NPC) cases occurring in Taiwan. A total of 133 informative microsatellite markers were used on chromosomes 3, 9, and 11 with an average marker density of 4 centimorgans (cM) for the allelotyping of genomic DNAs isolated from NPC tissues and their corresponding lymphocytes in 48 patients. The correlation between allelic loss and the clinicopathologic parameters of NPC tissues was examined. In addition, putative TSGs including FHIT, p16(INK4a), and p19(ARF) were selected for mutation screening to investigate their potential participation in NPC tumorigenesis. Of 3787 informative allelotyping data, 25 frequent allelic losses (or loss of heterozygosity [LOH]) in 13 cytogenetic loci were identified based on a deletion frequency that was greater than the average of all...Continue Reading

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Citations

Feb 1, 2007·Frontiers of Medicine in China·Yuping XiaoYan Xin
Jun 23, 2011·Molecular Cancer Research : MCR·Yemin WangToshiyasu Taniguchi
Jan 21, 2006·Journal of Translational Medicine·Xin LiFrancesco M Marincola
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Sep 2, 2016·Molecular Carcinogenesis·Yi JinLiang Gao
Jun 2, 2005·World Journal of Gastroenterology : WJG·Yu-Ping XiaoYan Xin
May 5, 2007·Expert Reviews in Molecular Medicine·Qian Tao, Anthony T C Chan
Jun 15, 2006·World Journal of Gastroenterology : WJG·Yu-Ping XiaoYan Xin

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