Definitions and Outcome Measures in Pediatric Functional Upper Gastrointestinal Tract Disorders: A Systematic Review

Journal of Pediatric Gastroenterology and Nutrition
Amara Nassar-Sheikh RashidMerit M Tabbers

Abstract

Functional disorders of the upper gastrointestinal tract are frequently diagnosed in children. Four different clinical entities are addressed by the Rome III committee: functional dyspepsia (FD), cyclic vomiting syndrome (CVS), adolescent rumination syndrome (ARS), and aerophagia. Management of these disorders is often difficult leading to a wide variety in therapeutic interventions. We hypothesize that definitions and outcome measures in these studies are heterogeneous as well. Our aim is to systematically assess how these disorders and outcomes are defined in therapeutic randomized controlled trials (RCTs). CENTRAL, Embase, and MEDLINE/PubMed were searched from inception to February 25, 2015. Search terms were FD, CVS, ARS, and aerophagia. Therapeutic RCTs, or systematic reviews of RCTs, in English language including subjects ages 4 to 18 years (0-18 years for CVS) were evaluated. Quality was assessed using the Delphi list. A total of 1398 articles were found of which 8 articles were included. Seven concerned FD and 1 concerned CVS. In all of the studies, Rome criteria or similar definitions were used; all the studies however used different outcome measures. Seventy-five percent of the trials were of good methodological quali...Continue Reading

References

May 11, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C C Boey, K L Goh
Oct 3, 2002·The American Journal of Gastroenterology·Natasha A KoloskiPhilip M Boyce
Oct 18, 2003·Gastroenterology Clinics of North America·B U Li, Larry Misiewicz
May 9, 2006·Gastroenterology·Andrée RasquinLynn S Walker
May 9, 2006·Gastroenterology·UNKNOWN Design of Treatment Trials CommitteeSander J O Veldhuyzen van Zanten
Jul 14, 2006·Current Treatment Options in Gastroenterology·Denesh K ChitkaraWilliam E Whitehead
Jan 19, 2007·Alimentary Pharmacology & Therapeutics·A GawrońskaH Szajewska
May 1, 2007·World Journal of Gastroenterology : WJG·Mahmood HaghighatMarzieh Nejabat
May 1, 2008·Clinical Pediatrics·Vera Loening-Baucke, Alexander Swidsinski
Apr 8, 2010·The American Journal of Gastroenterology·Lin Chang, Douglas A Drossman
Jan 18, 2011·Journal of Pediatric Gastroenterology and Nutrition·Brynie Slome Collins, Henry C Lin
Sep 17, 2011·Journal of Pediatric Gastroenterology and Nutrition·Niranga M Devanarayana, Shaman Rajindrajith
Feb 9, 2012·Journal of Pediatric Gastroenterology and Nutrition·Ashish ChogleMiguel Saps
May 29, 2012·European Journal of Gastroenterology & Hepatology·Lennard Y W LeeSimon Anderson
Jun 9, 2012·Annals of Nutrition & Metabolism·Berthold KoletzkoUNKNOWN Early Nutrition Academy and European Society for Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutritio
Jun 16, 2012·Annals of Nutrition & Metabolism·Berthold KoletzkoUNKNOWN European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)
Aug 14, 2012·Gastroenterology·Anne F PeeryNicholas J Shaheen
Dec 12, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M A L van TilburgA Langseder
May 30, 2013·World Journal of Gastroenterology : WJG·Andrea HorvathHania Szajewska
Jul 17, 2013·Journal of Pediatric Gastroenterology and Nutrition·Saeed MohammadMiguel Saps
Dec 18, 2013·The Journal of Pediatrics·Miguel SapsCarlos Alberto Velasco-Benítez
Apr 11, 2014·Pediatric Annals·Meenakshi Ganesh, Samuel Nurko
May 2, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·U P Phatak, D S Pashankar
May 7, 2014·Journal of Pediatric Gastroenterology and Nutrition·Nina F SteutelMerit M Tabbers
May 28, 2014·Experimental Brain Research·Reza A Hejazi, Richard W McCallum
Jul 30, 2014·Current Gastroenterology Reports·Hayat M MousaAnthony Alioto
Aug 19, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F CarboneJ Tack
Sep 28, 2014·Gut·Vincenzo Stanghellini, Jan Tack
Oct 8, 2014·Journal of Clinical Gastroenterology·Hania Szajewska, Jacek Karas
Nov 22, 2014·Archives of Disease in Childhood·Jacek KarasUNKNOWN Consensus Group on Outcome Measures Made in Paediatric Enteral Nutrition Clinical Trials (COMMENT)
Jan 6, 2015·The Journal of Pediatrics·Miranda A L van TilburgWilliam E Whitehead

❮ Previous
Next ❯

Citations

Jul 30, 2016·Journal of Pediatric Gastroenterology and Nutrition·Neha R SantucciSunny Z Hussain
Aug 11, 2018·Journal of Digestive Diseases·Ruben J ColmanDavid H Rubin
Oct 27, 2018·Expert Review of Clinical Pharmacology·Pamela D BrowneMerit M Tabbers
Apr 25, 2018·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Pablo ErcoliSergio Pinillos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.