Definitive Chemoradiation With Dose Escalation for Locally Advanced Gastric Cancer: Case Studies

Curēus
Michelle Anthony, Uma Goyal

Abstract

Gastric cancer is a prevalent cancer with a predilection for Asian ethnicity and male patients. In early and locally advanced gastric cancer, without significant comorbidities, surgery is a part of the treatment management of this cancer. However, with concurrent comorbidities, surgery may not be recommended and alternative treatment options such as palliative chemotherapy and/or radiation and definitive chemoradiation can be considered to reduce morbidity. We present three cases of gastric cancer where definitive chemoradiation with dose escalation was utilized due to underlying comorbidities and poor performance status. The treatment was generally well tolerated by patients and resulted in substantial reduction in gastric mass size in two patients with median overall survival of 10 months.

References

Apr 15, 2008·International Journal of Radiation Oncology, Biology, Physics·Michelle M KimSunil Krishnan
Sep 4, 2012·Journal of Gastrointestinal Oncology·Bing HuAurelia Meloni-Ehrig
Jul 4, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zheyu SongXuedong Fang
Jun 3, 2018·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Dilsa Mizrak KayaJaffer A Ajani
Aug 14, 2018·Journal of the National Comprehensive Cancer Network : JNCCN·Richard LiYi-Jen Chen

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Methods Mentioned

BETA
biopsy
surgical resection

Related Concepts

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Cancer Disparities

Cancer disparities refers to differences in cancer outcomes (e.g., number of cancer cases, related health complications) across population groups.

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