Definitive local therapy is associated with improved overall survival in metastatic cervical cancer

Practical Radiation Oncology
Sriram VenigallaS Beriwal

Abstract

Definitive local therapy is often used in metastatic cervical cancer to reduce morbidity associated with local tumor progression. However, the potential benefit of this therapeutic approach has not been rigorously investigated. We hypothesized that definitive local therapy is associated with improved overall survival (OS) in metastatic cervical cancer. Patients aged ≥18 years with newly diagnosed metastatic cervical cancer who were treated with chemotherapy were identified from the National Cancer Database. Patients were dichotomized into the following cohorts: definitive local therapy (defined as either concurrent chemoradiation therapy or definitive surgery) or conservative therapy (defined as systemic therapy with or without palliative radiation therapy). The association between definitive local therapy and OS was assessed using propensity score-weighted Cox proportional hazards models. Potential unmeasured confounding was assessed through sensitivity analyses. Factors associated with the receipt of definitive local therapy were identified with multivariable logistic regression. A total of 2838 patients were identified, of whom 1194 (42%) and 1644 (58%) were treated with definitive local and conservative therapy, respectivel...Continue Reading

References

Jun 1, 1992·Journal of Clinical Epidemiology·R A DeyoM A Ciol
Sep 2, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A ManeoC Mangioni
Jul 1, 1993·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·G.M. ThomasG. Rawlings
Oct 5, 2001·Lancet·G H MickischUNKNOWN European Organisation for Research and Treatment of Cancer (EORTC) Genitourinary Group
Jun 17, 2006·Statistics in Medicine·Nandita Mitra, Daniel F Heitjan
Feb 2, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Cornelis J A HaasbeekLukas J A Stalpers
Sep 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bradley J MonkDavid Cella
Apr 28, 2011·Nature Reviews. Clinical Oncology·Elizabeth ComenJoan Massagué
Feb 22, 2012·International Journal of Radiation Oncology, Biology, Physics·Henry S ParkJames B Yu
Mar 15, 2013·Journal of the National Comprehensive Cancer Network : JNCCN·Lois Ramondetta
Dec 31, 2015·Malawi Medical Journal : the Journal of Medical Association of Malawi·M J Bates, A Mijoya
Jun 9, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas SeisenQuoc-Dien Trinh
Jun 22, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chad G RusthovenThomas J Pugh
Mar 2, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
May 4, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·David M GuttmannSamuel Swisher-McClure
Jul 20, 2017·International Journal of Radiation Oncology, Biology, Physics·Tae Hun KimChul-Koo Cho

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Jul 2, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Emile GogineniAnuj Goenka
Nov 5, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Supriya ChopraRemi A Nout

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