PMID: 2102590Jan 1, 1990Paper

Definitive methods of zygosity determination in twins: relevance to problems in the biology of twinning

Acta geneticae medicae et gemellologiae
G Machin

Abstract

Many studies of embryogenesis and fate of twin pregnancies are invalidated because zygosity is not determined definitively, or is assumed on the basis of inadequate criteria. This paper briefly reviews methods of zygosity determination. It reports published results and a new series of twins in which zygosity was determined by DNA fingerprinting. Implications for methods of prenatal diagnosis of zygosity are discussed in the context of the occasional need for intervention in twin transfusion syndrome or in twins discordant for major malformations. Definitive zygosity and placental anatomy (number of chorions and amnions) is discussed as the firm substrate for studies of normal and abnormal twin development.

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Citations

Jan 1, 1997·Acta geneticae medicae et gemellologiae·C CharlemaineJ C Pons
Jan 1, 1992·Acta geneticae medicae et gemellologiae·W H James
Apr 15, 2015·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Ville VuolloTuomo Heikkinen
Nov 1, 1993·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·H EufingerE Machtens

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