PMID: 6402289Apr 15, 1983Paper

Definitive nonsurgical therapy of epithelial malignancies of the anal canal. A report of 12 cases

Cancer
M FlamB P Lau

Abstract

Twelve patients with epidermoid carcinoma of the anal region ranging in age from 40-89 years were treated with combined chemotherapy (CT) and radiotherapy (RT) in lieu of abdominal-perineal resection. Ten patients received no prior treatment and two patients were treated for local recurrence following limited surgical excision. Two courses of 5-FU infusion and mitomycin C were given 3-4 weeks apart simultaneously with whole pelvis RT to 3000-4140 rad. One patient received an additional tumor volume dose of 3094 rad by interstitial Iridium implant and one patient received an orthovoltage boost of 1000 rad to the anal ring. All patients completed treatment. Complete regression of the anal mass occurred in all patients. Biopsies of the anal region performed after completion of therapy revealed no evidence of residual cancer. Ten of the 12 patients are alive without evidence of disease 4-24 months (median, 14 months) after completion of treatment. Two patients have died seven months after treatment of unrelated causes and were tumor-free at autopsy. All patients developed proctitis, diarrhea, and moist perineal desquamation which resolved by four weeks posttreatment. Based on their experience and that of others recently reported, t...Continue Reading

References

Jan 1, 1978·Journal of Surgical Oncology·B L HintzA Sudarsanam
Nov 1, 1977·Diseases of the Colon and Rectum·T R BurokerV K Vaitkevicius
Jan 1, 1976·Cancer·H K Newman, S H Quan
May 1, 1974·Diseases of the Colon and Rectum·N D NigroB Considine
Mar 1, 1968·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·D S ChildsM Colby
Mar 1, 1981·Diseases of the Colon and Rectum·N D NigroB Considine
Jul 15, 1981·Cancer·R SinghA Mittelman
Aug 15, 1980·Cancer·E W Svenson, E D Montague
Jun 1, 1980·Current Problems in Cancer·M W StearnsF Attiyeh

❮ Previous
Next ❯

Citations

Nov 1, 1994·Diseases of the Colon and Rectum·D E Beck, R E Karulf
Sep 1, 1994·Diseases of the Colon and Rectum·M ChadhaA Berson
Jan 1, 1996·International Journal of Radiation Oncology, Biology, Physics·M JohnN Palma
Mar 16, 2000·The New England Journal of Medicine·D P RyanR J Mayer
Feb 1, 1992·Annals of Surgery·R DociG Lamonica
Jul 11, 2000·Current Opinion in Oncology·D P Ryan, R J Mayer
Dec 27, 2011·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·B De BariF Mornex
Oct 1, 1991·International Journal of Radiation Oncology, Biology, Physics·M Rotman, C S Lange
Mar 1, 1987·International Journal of Radiation Oncology, Biology, Physics·M J JohnP A Mowry
Nov 28, 2007·Clinical Colorectal Cancer·Alexander Lin, Edgar Ben-Josef
Jul 3, 2007·Journal of the American College of Radiology : JACR·Matthew M PoggiPeter A Johnstone
Aug 1, 1989·The British Journal of Surgery·M P PintorR J Nicholls
Jun 1, 1987·Journal of Surgical Oncology·J KlompjeA Mittelman
Sep 1, 1985·The British Journal of Surgery·M J GreenallJ J DeCosse
Apr 1, 1984·The Australian and New Zealand Journal of Surgery·K W Tiver, A O Langlands
Feb 1, 1985·The American Journal of Medicine·L LeichmanC Leichman
Nov 4, 2016·Acta Oncologica·Jon Espen DaleOlav Dahl
Jan 15, 1986·Cancer·J ClarkA Mittelman
May 12, 2007·Journal of Surgical Oncology·Yi-Wei ChenLing-Wei Wang
Jul 11, 2014·Current Treatment Options in Oncology·Shahab Ahmed, Cathy Eng
Jan 1, 1983·Medical and Pediatric Oncology·S J LeibachR J Brescia
Apr 4, 2021·Cancers·Edward Christopher DeeJennifer Y Wo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.