Definitive radiation therapy for endometrial cancer in medically inoperable elderly patients

Brachytherapy
Rodney E WegnerThomas C Krivak

Abstract

With the increasing elderly population, more women with newly diagnosed endometrial cancer may not be surgical candidates due to medical comorbidities. Definitive radiation therapy with external beam radiation (EBRT) and/or brachytherapy is a reasonable primary treatment for endometrial cancer in patients who cannot undergo surgery. A retrospective review identified 26 women 75 years and older with endometrial cancer who were not operative candidates due to comorbidities and received definitive radiation. The median age of the treated patients was 83, all of whom had significant medical comorbidities precluding surgical treatment. Seventy-three percent of the patients had stage T1 disease, 19% were stage T2, and 8% were stage T3. Seventy-three percent of patients received EBRT before brachytherapy (median dose: 45 Gy). The median brachytherapy dose was 20 Gy in 5 fractions. The types of brachytherapy used were Rotte Y applicator (42%), tandem and cylinder (42%), and ring and tandem (16%). Median followup was 12 months (1-60 months). No treatment breaks were required for the entire group and only 2 patients (8%) developed late toxicity. The overall survival for all patients was 89% and 28% at 1 and 2 years, respectively. Disease...Continue Reading

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Citations

Jan 30, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A FiorentinoV Fusco
Nov 10, 2015·Obstetrics and Gynecology·J Alejandro Rauh-HainMarcela G Del Carmen
Mar 28, 2018·BioMed Research International·Valentina LancellottaCynthia Aristei
Mar 30, 2017·Case Reports in Obstetrics and Gynecology·Asama VanichtantikulOrawee Chinthakanan
Mar 9, 2019·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Adélaïde RacinUNKNOWN groupe de recherche FRANCOGYN

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