Definitive radiotherapy for recurrent vulvar carcinoma after primary surgery: a two-institutional Italian experience

Tumori
Concetta LalisciaFabiola Paiar

Abstract

To assess the clinical outcome of patients treated with radiotherapy (RT) for recurrent squamous cell carcinoma of the vulva after primary surgery. Fifty-six patients developed recurrent disease after surgery, consisting of deep total vulvectomy with inguino-femoral lymphadenectomy in 44 (78.6%) and deep partial vulvectomy with inguino-femoral lymphadenectomy in 12 (21.4%). All patients underwent RT at the Divisions of Radiotherapy, University of Pisa and ASST Cremona, between 1992 and 2016. Forty-three patients (76.8%) underwent external beam RT and 13 (23.2%) were treated with exclusive high-dose rate brachytherapy. Five-year progression-free survival (PFS) and overall survival (OS) were 19% and 43%, respectively. Primary tumor size ⩽4 cm, early FIGO stage, and negative lymph node status were significantly associated with better PFS (p = .005, p = .020 and p = .036, respectively) and OS (p < .0001, p = .023 and p = .008, respectively). Patients with more than 1 positive lymph node at primary surgery had significantly worse PFS (p = .028) and OS (p = .001). Patients with local recurrence had significantly better PFS and OS (p = .022, p = .002, respectively). RT total dose >54 Gy was associated with a lower risk of recurrence. ...Continue Reading

References

Nov 1, 1992·American Journal of Obstetrics and Gynecology·A S TilmansN B Hornback
Nov 1, 1983·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H R WithersL J Peters
Nov 15, 1995·Cancer·H D Homesley
Sep 23, 1997·Gynecologic Oncology·D Cavanagh
Oct 21, 2000·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J L BenedetS Pecorelli
Sep 11, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·Kalyan K Dhar, Robert P Woolas
Sep 11, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·Peter Blake
Dec 24, 2003·American Heart Journal·JoAnne Micale FoodyHarlan M Krumholz
Feb 8, 2005·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M ArvasD Kösebay
Nov 16, 2005·Clinical Obstetrics and Gynecology·José Alberto Fonseca-Moutinho
Apr 7, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·K Reynen, U Köckeritz
Sep 2, 2006·Critical Reviews in Oncology/hematology·Angiolo GadducciAndrea Riccardo Genazzani
Dec 13, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·U BellerA P M Heintz
Feb 23, 2011·Archives of Gynecology and Obstetrics·C DittmerD Fischer
Oct 22, 2011·Critical Reviews in Oncology/hematology·Angiolo GadducciAndrea Riccardo Genazzani
Jan 24, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Linn WoelberSven Mahner
Jan 1, 2013·International Journal of Radiation Oncology, Biology, Physics·Sushil BeriwalThomas C Krivak
Aug 19, 2014·Best Practice & Research. Clinical Obstetrics & Gynaecology·Leonardo Micheletti, Mario Preti
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 18, 2016·Journal of Contemporary Brachytherapy·Sylwia Kellas-ŚlęczkaZofia Kołosza
Oct 30, 2016·Tumori·Piera SciaceroPierfrancesco Franco
Oct 26, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Divya NatesanJunzo Chino
Oct 26, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Pedro Martinez-CastroLucas Minig
Sep 18, 2016·Critical Reviews in Oncology/hematology·L S NooijM I E van Poelgeest
Jan 4, 2017·Journal of the National Comprehensive Cancer Network : JNCCN·Thanh H DellingerErnest S Han
Nov 1, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·U BellerApm Heintz

❮ Previous
Next ❯

Citations

Sep 30, 2020·Seminars in Diagnostic Pathology·Julia Chen, Hoang Ln
Mar 3, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·V LancellottaL Tagliaferri
Nov 29, 2020·Seminars in Diagnostic Pathology·Chen J Julia, L N Hoang

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.