Definitive radiotherapy for unresected adenoid cystic carcinoma of the trachea

Chest
Lara P Bonner MillarRamesh Rengan

Abstract

Adenoid cystic carcinoma is a rare malignancy that usually originates in the salivary glands of the head and neck but has rarely been known to originate in the trachea. This histology has a predilection for perineural invasion and a tendency for both local and distant recurrences. While surgical resection is the mainstay of treatment of tracheal adenoid cystic carcinoma, tumor size, location, and patient comorbidities may preclude surgery, and the optimal nonsurgical management remains undefined. In the absence of locoregional lymph node metastases, we recommend highly conformal radiotherapy alone to a dose of 80 Gy. We report on two patients with unresectable disease who were treated with definitive radiotherapy: one using conventional photons and one treated with a combination of photon and proton beams. Both patients were treated to a dose of 80 Gy with acceptable toxicities and objective clinical and radiographic response. The patient treated with conventional photons has no evidence of recurrent disease at 5 years; the patient treated with protons has continued evidence of response without evidence of disease recurrence 11 months after treatment.

References

Jan 1, 1990·The Annals of Thoracic Surgery·H C Grillo, D J Mathisen
Apr 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A Y Cheung
Jun 15, 1989·Cancer·J N FieldsB N Emami
Dec 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·D E MaziakF G Pearson
Nov 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·B JeremicS Milisavljevic
Dec 9, 1997·Japanese Journal of Clinical Oncology·K Y YangR P Perng
Nov 4, 1998·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R Prommegger, G M Salzer
May 21, 2003·Chest Surgery Clinics of North America·Henning A Gaissert
Nov 4, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Neil Bhattacharyya
Nov 25, 2004·The Annals of Thoracic Surgery·Henning A GaissertDouglas J Mathisen
Jan 5, 2005·International Journal of Radiation Oncology, Biology, Physics·Keith L MillerLawrence B Marks
Jan 4, 2006·The Lancet Oncology·Paolo Macchiarini
Feb 18, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Chris R KelseyLawrence B Marks
Dec 2, 2006·Annals of Surgical Oncology·Jimmie HoningsHenri A M Marres
Sep 1, 2007·The Cancer Journal·Sonal SuraKenneth E Rosenzweig
Dec 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aaron M AllenSteven J Mentzer
Apr 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Nathan BittnerJames G Douglas
May 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark A SocinskiEverett E Vokes
Dec 20, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Carrie B LeeMark A Socinski
Mar 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Lawrence B MarksAndrew Jackson

❮ Previous
Next ❯

Citations

Sep 28, 2014·General Thoracic and Cardiovascular Surgery·Hiroaki NomoriAkihiko Takeshi
Dec 17, 2014·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Hongwu WangJing Li
Jun 18, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jung Seop EomO Jung Kwon
Jul 15, 2015·Clinical Oncology : a Journal of the Royal College of Radiologists·A A L HsuA M P Takano
Apr 17, 2015·Case Reports in Otolaryngology·Thavakumar SubramaniamJames Paul O'Neill
Apr 8, 2016·Clinical Nuclear Medicine·Si-Yun WangGang Chen
Dec 3, 2016·Radiology and Oncology·Aleksandra NapieralskaSławomir Blamek
Jul 26, 2016·Molecular and Clinical Oncology·Turki AldreesSaleh F Aldhahri
Nov 20, 2016·Journal of Forensic Sciences·Butch HustonMichael McGee
Feb 2, 2019·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Wu-Tong JuLai-Ping Zhong
Apr 1, 2018·International Journal of Particle Therapy·Vivek VermaCharles B Simone
Mar 7, 2019·Journal of Medical Case Reports·Gian Paolo SpinelliSilverio Tomao
Aug 15, 2014·Oncology Letters·Wojciech KukwaAnna M Czarnecka
Nov 18, 2018·Revue des maladies respiratoires·K ThiamH Dutau
Aug 11, 2021·Technology in Cancer Research & Treatment·Ruifang ZengQiuyuan Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Katherine TriantafillidouDimitris Koufogiannis
Medicina oral, patología oral y cirugía bucal
Eduardo Costa Studart SoaresAna Paula Negreiros Nunes Alves
© 2021 Meta ULC. All rights reserved