Definitive radiotherapy with image-guided adaptive brachytherapy for primary vaginal cancer

The Lancet Oncology
Henrike WesterveldRemi A Nout

Abstract

Primary vaginal cancer is a rare cancer and clinical evidence to support recommendations on its optimal management is insufficient. Because primary vaginal cancer resembles cervical cancer in many aspects, treatment strategies are mainly adopted from evidence in locally advanced cervical cancer. To date, the organ-sparing treatment of choice is definitive radiotherapy, consisting of external beam radiotherapy and brachytherapy, combined with concurrent chemotherapy. Brachytherapy is an important component of the treatment and its steep dose gradient enables the delivery of high doses of radiation to the primary tumour, while simultaneously sparing the surrounding organs at risk. The introduction of volumetric CT or MRI image-guided adaptive brachytherapy in cervical cancer has led to better pelvic control and survival, with decreased morbidity, than brachytherapy based on x-ray radiographs. MRI-based image-guided adaptive brachytherapy with superior soft-tissue contrast has also been adopted sporadically for primary vaginal cancer. This therapy has had promising results and is considered to be the state-of-the-art treatment for primary vaginal cancer in standard practice.

References

Jul 1, 1977·Cancer·T PrempreeC A Cuccia
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·R G StockL B Harrison
Aug 11, 1991·American Journal of Obstetrics and Gynecology·G L EddyP B Underwood
Aug 1, 1991·Gynecologic Oncology·K P DavisP C O'Brien
Jun 1, 1987·Baillière's Clinical Obstetrics and Gynaecology·B G Lindeque
Oct 1, 1988·Radiology·Y C ChangC G Lacey
Feb 1, 1984·International Journal of Radiation Oncology, Biology, Physics·A MartinezG K Edmundson
Oct 1, 1982·Gynecologic Oncology·H G Ball, M L Berman
Jun 1, 1980·International Journal of Radiation Oncology, Biology, Physics·B L HintzM Wollin
Jul 30, 1994·International Journal of Radiation Oncology, Biology, Physics·W R LeeR R Million
Jan 1, 1993·Gynecologic Oncology·S DixitH A Baboo
Feb 1, 1996·American Journal of Clinical Oncology·B A FineD Driscoll
Jul 15, 1996·International Journal of Radiation Oncology, Biology, Physics·V ChyleL Delclos
Apr 29, 1999·International Journal of Radiation Oncology, Biology, Physics·C A PerezM A Lockett
Feb 3, 2000·International Journal of Radiation Oncology, Biology, Physics·S PingleyK A Dinshaw
Jul 21, 2000·Australasian Radiology·F ForoudiV Gebski
May 24, 2001·Gynecologic Oncology·W A TjalmaJ J Weyler
Jan 29, 2002·Gynecologic Oncology·Tsutomu TabataKatsuhiko Hasumi
Sep 27, 2003·The British Journal of Radiology·D M KushnerP A Saffle
Mar 15, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christine Haie-MederUNKNOWN Gynaecological (GYN) GEC-ESTRO Working Group
Apr 27, 2005·International Journal of Radiation Oncology, Biology, Physics·Steven J FrankPatricia J Eifel
Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·Wayne T LamoreauxBarry A Siegel
Nov 2, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Rajiv SamantChoan E
Feb 13, 2007·Gynecologic Oncology·Steven J FrankPatricia J Eifel
May 1, 2007·Clinical Radiology·M B TaylorB M Carrington
May 22, 2007·International Journal of Radiation Oncology, Biology, Physics·Rajiv SamantTiffany Tam
Oct 30, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Renaud de CrevoisierChristine Haie-meder
Jan 22, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jyoti H ParikhS Aslam Sohaib
Aug 30, 2008·Gynecologic Oncology·Jidong LianRobert Pearcey
Dec 31, 2008·International Journal of Cancer. Journal International Du Cancer·Hugo De VuystSilvia Franceschi
Mar 27, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·UNKNOWN FIGO Committee on Gynecologic Oncology
May 5, 2009·Gynecologic Oncology·Angelo MaggioniC Paul Morrow
Jun 11, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Bedatri SinhaHiginia Cardenes
Dec 19, 2009·Current Opinion in Obstetrics & Gynecology·Martine Franckena, Jacoba van der Zee
Sep 20, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Lars FokdalJacob Christian Lindegaard
Jan 24, 2012·Brachytherapy·Sushil BeriwalUNKNOWN American Brachytherapy Society
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal

❮ Previous
Next ❯

Citations

Sep 24, 2020·Drug Development and Industrial Pharmacy·Dan Hong, Hong-Mei Zhao
Nov 10, 2020·Gynecologic Oncology·Christopher D GoodmanDavid P D'Souza
May 18, 2020·International Journal of Radiation Oncology, Biology, Physics·Steven De MichinoScott V Bratman
Aug 3, 2021·Abdominal Radiology·Rachel SteinChandana Lall
Nov 11, 2020·Clinical Oncology : a Journal of the Royal College of Radiologists·M Ingle, S Lalondrelle
Sep 22, 2021·Acta Obstetricia Et Gynecologica Scandinavica·Christina L RasmussenSusanne K Kjaer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.