Defocused Imaging of UV-Driven Surface-Bound Molecular Motors

Journal of the American Chemical Society
Bartosz KrajnikJohan Hofkens

Abstract

Synthetic molecular motors continue to attract great interest due to their ability to transduce energy into nanomechanical motion, the potential to do work and drive systems out-of-equilibrium. Of particular interest are unidirectional rotary molecular motors driven by chemical fuel or light. Probing the mechanistic details of their operation at the single-molecule level is hampered by the diffraction limit, which prevents the collection of dynamic positional information by traditional optical methods. Here, we use defocused wide-field imaging to examine the unidirectional rotation of individual molecular rotary motors on a quartz surface in unprecedented detail. The sequential occupation of nanomechanical states during the UV and heat-induced cycle of rotation are directly imaged in real-time. The approach will undoubtedly prove important in elucidating the mechanistic details and assessing the utility of novel synthetic molecular motors in the future.

References

Sep 18, 1999·Nature·N KoumuraB L Feringa
Jun 7, 2000·Proceedings of the National Academy of Sciences of the United States of America·K AdachiK Kinosita
Jul 11, 2003·Nature·David A LeighFrancesco Zerbetto
Nov 4, 2004·Journal of the American Chemical Society·Wouter SchroeyersFrans C De Schryver
Apr 14, 2005·Chemical Reviews·Gregg S KottasJosef Michl
Aug 30, 2005·Nature Materials·José BernáFrancesco Zerbetto
Mar 10, 2006·Nature·Rienk EelkemaBen L Feringa
Jul 21, 2006·The Journal of Physical Chemistry. B·Mark A Osborne
Jul 19, 2008·Journal of the American Chemical Society·Martin KlokBen L Feringa
Jul 26, 2008·Nature Nanotechnology·Wesley R Browne, Ben L Feringa
Mar 3, 2010·Cold Spring Harbor Protocols·Samara L Reck-PetersonNico Stuurman
Mar 31, 2010·The Journal of Physical Chemistry. a·Andranik KazaryanMichael Filatov
Jun 1, 2013·Science·Dimas G de OteyzaFelix R Fischer
Jan 21, 2014·Nature Nanotechnology·James A HutchisonJohan Hofkens
Jun 12, 2014·Journal of the American Chemical Society·Jamie ConyardStephen R Meech
Apr 2, 2015·Journal of the American Chemical Society·Chayasith UttamapinantJason W Chin
Sep 9, 2015·Chemical Reviews·Sundus Erbas-CakmakAlina L Nussbaumer
Mar 5, 2016·Chemical Society Reviews·Matthew A Watson, Scott L Cockroft
Aug 2, 2016·Journal of the American Chemical Society·Saumya SaurabhW E Moerner

❮ Previous
Next ❯

Citations

Nov 1, 2018·Organic & Biomolecular Chemistry·Kerstin HoffmannHenry Dube
Jan 21, 2020·Advanced Materials·Stefano CorraAlberto Credi
Jan 4, 2020·Angewandte Chemie·Chang-Bo HuangPaolo Samorì
Aug 16, 2019·Chemical Reviews·Massimo BaronciniAlberto Credi
May 10, 2018·The Journal of Organic Chemistry·Jiawen ChenBen L Feringa
Dec 19, 2019·Chemical Reviews·Víctor García-LópezJames M Tour
Aug 14, 2020·Nano Letters·Anup SinghaniaAnirban Bandyopadhyay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved