PMID: 8970919Jan 1, 1997Paper

Deformation-induced hierarchical flows and drag forces in bone canaliculi and matrix microporosity

Journal of Biomechanics
A F MakP Tong

Abstract

Existing theories for interstitial flows in bone have only examined the contributions from different flow systems separately, such as the flows through the microporosity, the canaliculi, and the Haversian canals. An overall model encompassing the hierarchical microstructure is important to our understanding of the actual physics of flows in bone. The flow-induced drag forces and streaming electrical potentials could interact with the osteocytes to effect biological responses. A finite element model was developed to study the contributions from various hierarchical flow channels in bone. Cortical bone is modelled as a fully hydrated biphasic poroelastic material with a superposing network of one-dimensional channels radiating from the Haversian canals representing the canaliculi. Interfacial cross-flows between these one-dimensional channels and the neighbouring poroelastic matrix are driven by the pressure differences between the matrix and the channel. The model was subjected to stress fields simulating uniform compression and pure bending. The effects of the interfacial permeability and the solid content within the channels on the drag forces in the channels were assessed. Abrupt changes in these drag forces occurred as the c...Continue Reading

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Citations

Apr 12, 2006·Clinical Oral Investigations·Tonino TrainiAdriano Piattelli
Apr 14, 2007·Biomechanics and Modeling in Mechanobiology·D D Deligianni, C A Apostolopoulos
Dec 27, 2011·Biomechanics and Modeling in Mechanobiology·T LemaireS Naili
Feb 16, 2005·Annals of Biomedical Engineering·Eric J AndersonMelissa L Knothe Tate
Jul 10, 2007·Annals of Biomedical Engineering·Pere FornellsManuel Doblaré
Nov 24, 2012·Journal of Biomechanics·Luis CardosoStephen C Cowin
Sep 23, 2003·Journal of Biomechanics·Melissa L Knothe Tate
Mar 27, 1999·Journal of Biomechanics·S C Cowin
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Jun 24, 2008·Computer Methods in Biomechanics and Biomedical Engineering·G C GouletR F Zernicke
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Jan 15, 2010·Annual Review of Fluid Mechanics·Susannah P Fritton, Sheldon Weinbaum
Apr 10, 2013·Biomechanics and Modeling in Mechanobiology·Stefaan W VerbruggenLaoise M McNamara
Feb 24, 2004·Medical & Biological Engineering & Computing·M MullenderJ Klein-Nulend
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Mar 13, 2002·JONA'S Healthcare Law, Ethics and Regulation·C M Baker
Feb 8, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Kyriaki Skartsila, Nikos Spanos

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