Deformation of human red blood cells in extensional flow through a hyperbolic contraction

Biomechanics and Modeling in Mechanobiology
Mohammad M Faghih, M Keith Sharp

Abstract

Flow-induced damage to red blood cells has been an issue of considerable importance since the introduction of the first cardiovascular devices. Early blood damage prediction models were based on measurements of damage by shear stress only. Subsequently, these models were extrapolated to include other components of the fluid stress tensor. However, the expanded models were not validated by measurements of damage in response to the added types of stress. Recent investigations have proposed that extensional stress might be more damaging to red cells than shear stress. In this study, experiments were conducted to compare human red cell deformation under laminar extensional stress versus laminar shear stress. It was found that the deformation caused by shear stress is matched by that produced by an extensional stress that is approximately 34 times smaller. Assuming that blood damage scales directly with cell deformation, this result indicates that mechanistic blood damage prediction models should weigh extensional stress more than shear stress.

References

Mar 1, 1972·Biophysical Journal·L B LeverettE C Lynch
Sep 1, 1980·The Journal of Clinical Investigation·N MohandasS B Shohet
Jan 1, 1980·Biorheology·G Heuser, R Opitz
Jul 1, 1995·Artificial Organs·C Bludszuweit
Jan 1, 1965·Transactions - American Society for Artificial Internal Organs·P L BLACKSHEARJ H STEINBACH
May 21, 2010·Biophysical Journal·Dmitry A FedosovGeorge Em Karniadakis
Feb 8, 2011·Annals of Biomedical Engineering·Linden A DownEdgar A O'Rear
Apr 13, 2011·Biomicrofluidics·P C SousaM A Alves
Aug 4, 2011·Artificial Organs·Tao ZhangZhongjun J Wu
Oct 4, 2011·Biophysical Journal·Himanish BasuDeepak Mathur
Dec 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jules DupireAnnie Viallat
Apr 23, 2015·Artificial Organs·Jun DingZhongjun J Wu
Sep 23, 2016·Journal of Biomechanical Engineering·Mohammad M Faghih, M Keith Sharp
Jan 5, 2018·Biomechanics and Modeling in Mechanobiology·Mohammad M Faghih, M Keith Sharp
Aug 25, 2018·The International Journal of Artificial Organs·Dominica Py KhooKatharine H Fraser
Dec 28, 2018·Artificial Organs·Mohammad M Faghih, Michael Keith Sharp
Mar 9, 2019·Biomechanics and Modeling in Mechanobiology·Mohammad M Faghih, M Keith Sharp

❮ Previous
Next ❯

Citations

Aug 15, 2020·Journal of Biomechanical Engineering·Mohammad M FaghihM Keith Sharp
Mar 7, 2021·Cardiovascular Engineering and Technology·Lucas KonnigkFrank-Hendrik Wurm
Jun 10, 2021·Biomechanics and Modeling in Mechanobiology·Mesude AvciDimitrios V Papavassiliou
Nov 14, 2021·Cardiovascular Engineering and Technology·Marco MartinolliChristian Vergara

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.