Deformity of the femoral head following vascular infarct in piglets

Acta Orthopaedica
Sung Man RoweHyoung Yeon Seo

Abstract

In Legg-Calvé-Perthes disease (LCPD), 4 major patterns (coxa plana, coxa magna, coxa vara, subluxation) of the femoral head are commonly observed. However, direct observation of pathological specimens is rarely possible. An animal model of LCPD may clarify the pathogenesis of femoral head deformity. In 26 piglets, we interrupted the vascular supply to the capital femoral epiphysis by cutting the ligamentum teres and ligating the femoral neck containing the epiphyseal artery. 6-7 piglets in each experimental group were killed at early (2 and 4 weeks: P2 and P4), intermediate (12 weeks: P12), and late (20 weeks: P20) periods. We examined the extracted femoral heads macroscopically and radiographically. The mean decrease in epiphyseal height was 1.5 mm, 4.1 mm, 5.0 mm, and 7.5 mm in P2, P4, P12 and P20, respectively (rs = 0.76, p = 0.002). The mean increase of diameter was 4.1 mm, 6.9 mm, and 6.8 mm in P4, P12 and P20, respectively. Decrease of the articulotrochanteric distance was mild in P2 and P4, and severe in P12 and P20. Subluxation of the femoral head was observed only in P12 and P20 piglets. The piglet model of LCPD was useful in the early stage of devascularization for investigation of the developmental pattern of femoral...Continue Reading

References

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Nov 30, 2000·Journal of Pediatric Orthopedics·J C AbrilM Ferrer-Torrelles
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Citations

Jan 21, 2014·Revista española de cirugía ortopédica y traumatología·S Martínez-ÁlvarezF Forriol
Dec 6, 2008·Hematology·M Cemalettin AksoyMumtaz Alpaslan
Feb 11, 2015·Calcified Tissue International·Olumide O AruwajoyePranesh B Aswath

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