DeFries-Fulker and Pearson-Aitken model-fitting analyses of reading performance data from selected and unselected twin pairs

Behavior Genetics
Jesse L HawkeJohn C DeFries

Abstract

Although a comparison of concordance rates for deviant scores in identical and fraternal twin pairs can provide prima facie evidence for a genetic etiology, information is not fully utilized when continuous measures are analyzed in a dichotomous manner. Thus, DeFries and Fulker (Behav Genet 15:467-473, 1985; Acta Genet Med Gemellol, 37:205-216, 1988) developed a regression-based methodology (DF analysis) to assess genetic etiology in both selected and unselected twin samples. While the DF analysis is a very versatile and relatively powerful statistical approach, it is not easily extended to the multivariate case. In contrast, structural equation models may be readily extended to analyze multivariate data sets (Neale and Cardon, Methodology for genetic studies of twins and families, 1992). However, such methodologies may yield biased estimates of additive genetic, shared environmental, and non-shared environmental influences when multivariate models are fitted to selected twin data. Therefore, the Pearson-Aitken (PA) selection formula (Aitken, Proc Edinburgh Math Soc B, 4:106-110, 1934) was used to analyze reading performance data from twins with reading difficulties (selected sample) and a population of normally-achieving twin ...Continue Reading

References

Jan 1, 1988·Acta geneticae medicae et gemellologiae·J C DeFries, D W Fulker
Sep 1, 1985·Behavior Genetics·J C DeFries, D W Fulker
Jan 1, 1966·Acta Genetica Et Statistica Medica·R C Nichols, W C Bilbro
Jul 1, 1982·Behavior Genetics·N G Martin, S R Wilson
Feb 1, 1995·Journal of Learning Disabilities·J G Light, J C DeFries
Mar 1, 1997·Behavior Genetics·M C Neale, M B Miller
Mar 4, 2006·Dyslexia : the Journal of the British Dyslexia Association·Jesse L HawkeJohn C DeFries

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Citations

Oct 4, 2012·Homo : internationale Zeitschrift für die vergleichende Forschung am Menschen·G TemajJ Miličić

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