PMID: 9007583Jan 1, 1997Paper

Degeneration of axons in the brainstem of the chinchilla after auditory overstimulation

Hearing Research
J KimB A Bohne

Abstract

The patterns of axonal degeneration following acoustic overstimulation of the cochlea were traced in the brainstem of adult chinchillas. The Nauta-Rasmussen method for axonal degeneration was used following survivals of 1-32 days after a 105 min exposure to an octave-band noise with a center frequency of 4 kHz and a sound pressure level of 108 dB. Hair-cell and myelinated nerve-fiber loss were assessed in the cochlea. The cochleotopic pattern of terminal degeneration in the ventral cochlear nucleus correlated with the sites of myelinated fiber and inner-hair-cell loss: this correlation was less rigorous with outer-hair-cell loss, especially in the dorsal cochlear nucleus. These results are consistent with a dystrophic process with a slow time course depending on hair-cell loss and/or direct cochlear nerve-fiber damage. However, in a number of cases with no damage in the apical cochlea, fine fiber degeneration occurred with a faster course in low-frequency regions in the dorsal cochlear nucleus and, transynaptically, in a non-cochleotopic pattern in the superior olive and inferior colliculus. These findings suggest that neuronal hyperactivity plays a role in the central degeneration following acoustic overstimulation, possibly b...Continue Reading

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Citations

May 11, 2005·Neuroscience Letters·Dietmar BastaArne Ernst
Aug 30, 2000·Hearing Research·R J SalviD Ding
Apr 2, 1999·The European Journal of Neuroscience·F A Russell, D R Moore
May 27, 2011·Journal of Neurotrauma·Annekatrin CoordesDietmar Basta
Sep 22, 2011·Journal of Neurotrauma·Johnny C MaoJinsheng Zhang
Apr 29, 2014·Brain Research·Jake R Carpenter-ThompsonFatima T Husain
May 16, 2002·Experimental Neurology·J ZhangS J Potashner
Aug 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Abderrahman El MaaroufUrs Rutishauser
Dec 15, 2010·Hearing Research·James A Kaltenbach
Jun 21, 2012·Journal of Neuroscience Research·Tetsuji SekiyaBarbara Canlon
Jun 19, 2014·Journal of Neuroscience Research·Hao LuoJinsheng Zhang
Nov 24, 2011·Journal of Neuroscience Research·J FengD K Morest
Sep 15, 2004·Brain Research. Molecular Brain Research·Yumi MunemotoTetsuo Sugimoto
Jun 18, 2015·Frontiers in Neural Circuits·Zhiji Chen, Wei Yuan
Aug 6, 2005·Hearing Research·Robert-Benjamin IllingMarkus A Meidinger
Nov 21, 2007·Acta Oto-laryngologica. Supplementum·Young-Jin KimJong Woo Chung
Aug 13, 2014·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Leon ChenAna H Kim
May 30, 1998·Microscopy Research and Technique·M D McGinn, B T Faddis
Jan 27, 2004·Journal of Neuroscience Research·S M MulyS J Potashner

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