PMID: 3772403Oct 1, 1986Paper

Degeneration of myelinated sympathetic nerve fibres following treatment with guanethidine

Journal of Neurocytology
G J KiddP R Dunkley

Abstract

The specificity and characteristics of the degeneration of myelinated axons after chronic guanethidine treatment have been investigated in sympathetic and non-sympathetic nerves. Adult male Sprague-Dawley rats aged approximately 43 weeks were treated with guanethidine sulphate (50 mg per kg body weight per day) for between ten days and six weeks. Tissues were examined by qualitative and quantitative light and electron microscopy. In the superior cervical (sympathetic) ganglion (SCG), guanethidine treatment produced a 78% decrease (P = 0.009) in the mean number of myelinated fibres at a standard level of section, compared to the contralateral control ganglion which was removed surgically prior to drug treatment. This reduction in the treated SCG was apparent after 10 days, though complete degeneration of nerve cell bodies was not widespread at this stage. Degeneration of unmyelinated axons was extensive. Degenerating myelinated fibres were consistently small in diameter (up to approximately 3 microns). In individual myelinated fibres the earliest signs of degeneration involved disruption of axonal organelles, particularly the cytoskeleton, and focal widening of the periaxonal space. Myelin breakdown followed these events; degene...Continue Reading

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Citations

Mar 1, 1989·Biulleten' eksperimental'noĭ biologii i meditsiny·S N Riashchikov, V A Glumova
Jul 22, 1991·Neuroscience Letters·J W HeathP R Dunkley
Jan 1, 1992·The Journal of Cell Biology·G J KiddP R Dunkley
Aug 3, 2010·Journal of Korean Medical Science·Cenk KilicMurat Kocaoglu

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