PMID: 7525597Nov 1, 1994Paper

Degeneration of neural cells in the central nervous system of mice deficient in the gene for the adhesion molecule on Glia, the beta 2 subunit of murine Na,K-ATPase

The Journal of Cell Biology
J P MagyarMelitta Schachner

Abstract

We generated mice, null mutant in the adhesion molecule on glia (AMOG), the beta 2 subunit of the murine Na,K-ATPase gene. These mice exhibit motor incoordination at 15 d of age, subsequently tremor and paralysis of extremities, and die at 17-18 d after birth. At these ages, the mutants have enlarged ventricles, degenerating photoreceptor cells, and swelling and degeneration of astrocytic endfeet, leading to vacuoles adjoining capillaries of brain stem, thalamus, striatum, and spinal cord. In tissue homogenates from entire brains of 16-17-d-old mutants, Na,K-ATPase activity and expression of the beta 1 subunit of the Na,K-ATPase and of the neural adhesion molecules L1, N-CAM, and MAG appear normal. We suggest that the mutant phenotype can be related primarily to reduced pump activity, with neural degeneration as a possible consequence of osmotic imbalance.

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Citations

Nov 15, 1995·Experientia·B S Shastry
Apr 1, 1995·Trends in Neurosciences·M Schachner, R Martini
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Mar 23, 2000·Theriogenology·A J WatsonL C Barcroft
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Feb 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Noriaki KitamuraKiyoshi Furukawa
Feb 6, 2016·Scientific Reports·Florian HilbersHanne Poulsen
Feb 8, 2005·The Journal of Physiology·Hai LinMasumi Inoue
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Aug 21, 2003·Biochemical and Biophysical Research Communications·Yoshihide OheTakashi Matozaki
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Apr 6, 2002·Canadian Journal of Physiology and Pharmacology·Gerald M Kidder

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