PMID: 8469429Mar 5, 1993Paper

Degeneration of rat thalamic reticular neurons following intrathalamic domoic acid injection

Neuroscience Letters
E B Friedberg, D T Ross

Abstract

Domoic acid (DA), an analog of kainic acid, produces attentional deficits in humans who have ingested shell fish contaminated with this excitotoxin. The thalamic reticular nucleus (RT), by virtue of its location, connections and intrinsic properties, has been implicated in attentional processes. This study demonstrated the vulnerability of RT neurons following intrathalamic DA injections in rats. Lesions were characterized by almost total neuronal loss throughout the RT and sparing of adjacent populations of relay neurons in the VL and VPL. Los of RT neurons may underlie some types of attentional deficits observed in humans following DA poisoning.

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Citations

Dec 18, 2001·The Journal of Comparative Neurology·S WangS M Sherman
Oct 30, 2001·Neuroscience·J StehbergF Torrealba
Jun 10, 2009·Toxicon : Official Journal of the International Society on Toxinology·Kathi A Lefebvre, Alison Robertson
Oct 1, 2008·Behavioural Brain Research·Ofir PicazoMartha Garcia-Ramirez
Aug 7, 2004·Brain Research. Brain Research Reviews·Didier Pinault
Jul 28, 2011·Neuron·Yuri B Saalmann, Sabine Kastner
Jul 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D T Ross, D I Graham
Jun 10, 2016·Journal of Neurophysiology·Charlotte Deleuze, John R Huguenard

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